BREAKING NEWS, Putin takes on Big Pharma, Aeroplane crash, Zelenko seriously ill, Tess Lawrie report.

Plane crash Dr Madej

Dr Madej had just texted me on Thursday to state that she would not be doing public speaking events for several months as the medical board is coming after her full force.

On Tuesday, Dr Carrie Madej was involved in a small plane crash alongside her boyfriend. Both are in the hospital with multiple fractures, and her boyfriend has a broken back and fractured skull.

Dr Madej’s website is hosting a zoom prayer this evening at 6:30 PM EST. There are 100 spaces open to anyone who would like to pray. They are also streaming it on Instagram.

Dr Carrie Madej Involved In Plane Crash – Pray 🙏

“Dr. Carrie Madej was involved in a small plane crash alongside her boyfriend. Both are in the hospital with multiple fractures, and her boyfriend has a broken back and fractured skull.

Dr Madej is in ICU and she is expected to be released possibly on Tuesday.”

WARM SPRINGS, Ga. — The Federal Aviation Administration is investigating a plane crash in Meriwether County on Sunday.

A pilot and passenger crashed at Roosevelt Memorial Airport in Warm Springs after reporting engine trouble. The two landed in the field north of the airport, according to the FAA.

It happened around 2:15 p.m. The FAA said they were flying a single-engine Piper PA-24.

According to Michael Watson, the chairman of the Meriwether County Airport Authority, the flight was on the way from St. Petersburg, Florida, near Tampa, to Newnan-Coweta County Airport, when it experienced an engine issue as the plane started its descent. The flight was diverted south to Warm Springs, but crashed. Flight tracking website Flight Aware shows the path of the flight before the crash.

The FAA is working with the National Transportation Safety Board to determine a cause for the crash. Neither agency would provide specifics of the investigation.

Electronically tag innocent people

Regular readers will know I hold out no hope that petitions will make a difference. However, I do think they can give us a mutual boost that we’re not alone.

In any case, while I recommend you sign the petition, even more, important is that you become aware of just how terrible these laws about to come into force are. How utterly without precedent they are. Democracy has ended. It’s illegal to protest if at any time the authorities decide they don’t want you demonstrating.

Best wishes Mike Yeadon.

To: Priti Patel, Home Secretary

Don’t electronically tag innocent people for attending protests

https://you.38degrees.org.uk/petitions/don-t-put-innocent-campaigners-on-tag

Update on Dr. Zelenko:

As it was mentioned last night he has been intubated in the ICU after being put through a very intense and extreme last-hope type of treatment yesterday. They were able to get about 2/3 of the treatment finished before they had to stop due to extremely high blood pressure from the procedure. He started to stabilize throughout last night.

This morning things changed quickly and it looked like we were about to lose Zev for sure everyone that was there prayed over him intensely for a miracle. Then that miracle happened and he started to recover, which seemed impossible. This SHOCKED the doctors and nurses as they didn’t understand how it was happening!

He is still not in the clear yet but I thought you would all like to hear this update… please continue to pray for Zev!

Also, I have more info to share that is VERY positive but I want to wait and make sure it’s ok to go out first.

The vaccines damage fertility.

Firstly before Tess’ article, I just want to reiterate what you have read above is by no means a coincidence with Dr Madej. Just like the 74 spontaneous combustible food processing plants in the States.

Dave

Is this part of a depopulation agenda or ‘just’ a terrible mistake?

Given everything we know about the pandemic – that Covid is eminently treatable, the vaccines are neither safe nor effective, and millions have been injured as a direct result – why is the vaccine roll-out being allowed to continue?

More to the point, why were vaccines even rolled out in the first place?

There are many theories, ranging from the sinister to the plain venal. One of these is that a global elite believes that the planet is overcrowded and has implemented the pandemic and associated vaccine roll-out as part of a depopulation agenda.

It sounds the stuff of movies, and yet there is a precedent. As Dr Andrew Wakefield’s poignant new documentary, Infertility: A Diabolical Agenda, explains, the World Health Organisation spent many years researching and developing vaccines that would render recipients infertile. This line of research came from concern that populations were increasing at an unsustainable rate – and as the documentary reveals, the WHO saw fit to implement its infertility vaccines without the informed consent of the women and girls who received them.

If you haven’t already, please do watch the documentary and share it with others so that we can start discussing these matters together and in the open.

Many concerns have been raised over the impact of Covid-19 vaccines on fertility. The original Pfizer biodistribution studies (English translation here) reveal that the lipid nanoparticle (LNP) used to encapsulate the mRNA does not remain at the injection site as stated but travels to major organs including the spleen, liver, adrenal glands, the testes and the ovaries.

What is the impact of having toxic LNP accumulate in the reproductive organs? That’s the problem with inadequately tested medical interventions: we have no idea. However, data regarding reproductive health and fertility continue to mount.

Now, a new peer-reviewed study, accepted for publication in the journal Andrology, reveals the Covid-19 vaccines are harming male fertility.

Why is the WHO not investigating this?

We need to call these regulators to account – but we also need to ensure we ourselves do not fall for the lie that humanity is nothing more than a scourge on this planet. Instead, we can remember who we are: creative, intelligent, inspired beings with the capacity to dream up brilliant solutions to complex problems, and to care for our planet and each other.

Rather than passive consumers, we are active participants in the glorious web of life, and human fertility is to be treasured as the miracle that it is. If there is even the hint of a medical intervention damaging people’s fertility it must be halted. The vaccines must be halted. In the meantime, no more injections for healthy people. Until we can know they are completely safe,

Tess Lawrie

However, I have read that UK scientists have now blamed infertility, miscarriages and baby deaths on. Drumroll, please. “ Climate Change “

Dave

Putin vs Big Pharma: The ultimate smackdown

Is Putin plotting to purge the pill peddlers? If so, we have some suggestions

Is Vladimir Putin preparing to cleanse Russia of Big Pharma shills (his entire cabinet)? Some seem to think so and there is certainly evidence that some kind of anti-shill crackdown is coming. Let’s explore this intriguing news item together.

Take the wheel, TASS:

Russian President Vladimir Putin has criticized foreign drug companies for pushing their products through local medical institutions and via doctors in Russia using their deep-pocketed resources.

“Unfortunately, foreign pharmaceutical companies attracted some heads of our medical institutions and medical workers in 30 regions. And they pushed their medicines [on to the Russian market], paying quite a lot of money for it. We saw that under just one scheme they doled out 500 million [rubles],” he said at a meeting with Yury Chikhanchin Head of the Federal Financial Monitoring Service.

Putin noted that such practice also exists in the EU and worldwide.

“They do it everywhere. They do it in Europe and overseas too. This is how they operate,” he said.

Chikhanchin responded by saying his agency was working with the FSB to root out gratuitous Big Pharma grifting.

First of all: At the very least Putin deserves a golf clap for saying rude things about Big Pharma. No one loses points for doing that. So we salute you, Vladimir Putin. Keep it up.

At the same time: talk is cheap. If you’re going to launch a Novichok rocket at Big Pharma for “pushing their products through local medical institutions” (as TASS summarized) in 30 regions… this doesn’t exactly sound like the cleansing enema that Russia so desperately needs.

If Putin is sincere about expelling degenerate pill pushers from Russia, how far is he willing to go? Because in order to have a meaningful impact he’ll have to go pretty far. All the way, actually.

You need to cut the head off the snake. And the snake lives in Moscow. The snake has wrapped its slimly reptile-bod around various federal ministries. The snake is suffocating Russia at the highest levels of government.

That’s just a fact.

By

In the end, there can be only one.

Is Vladimir Putin preparing to cleanse Russia of Big Pharma shills (his entire cabinet)? Some seem to think so and there is certainly evidence that some kind of anti-shill crackdown is coming. Let’s explore this intriguing news item together.

Take the wheel, TASS:

Russian President Vladimir Putin has criticized foreign drug companies for pushing their products through local medical institutions and via doctors in Russia using their deep-pocketed resources.

“Unfortunately, foreign pharmaceutical companies attracted some heads of our medical institutions and medical workers in 30 regions. And they pushed their medicines [on to the Russian market], paying quite a lot of money for it. We saw that under just one scheme they doled out 500 million [rubles],” he said at a meeting with Yury Chikhanchin, Head of the Federal Financial Monitoring Service.

Putin noted that such practice also exists in the EU and worldwide.

“They do it everywhere. They do it in Europe and overseas too. This is how they operate,” he said.

Chikhanchin responded by saying his agency was working the FSB to root out gratuitous Big Pharma grifting.

First of all: At the very least Putin deserves a golf clap for saying rude things about Big Pharma. No one loses points for doing that. So we salute you, Vladimir Putin. Keep it up.

At the same time: talk is cheap. If you’re going to launch a Novichok rocket at Big Pharma for “pushing their products through local medical institutions” (as TASS summarized) in 30 regions… this doesn’t exactly sound like the cleansing enema that Russia so desperately needs.

If Putin is sincere about expelling degenerate pill pushers from Russia, how far is he willing to go? Because in order to have a meaningful impact he’ll have to go pretty far. All the way, actually.

You need to cut the head off the snake. And the snake lives in Moscow. The snake has wrapped its slimly reptile-bod around various federal ministries. The snake is suffocating Russia at the highest levels of government.

That’s just a fact.

Maybe it’s time for a “performance review” at the Ministry of Health? (source)

If tomorrow the FSB announces it bagged the deputy director of a village clinic in Potato-Patch, Yakutia, this will not qualify as a successful crackdown on Big Pharma’s nefarious influence in Russia. It will qualify as a massive fail.

So which Big Pharma Strumpets should be Gitmo’d by the FSB? We’re so glad you asked.

All of the Important Russians who partied with Tedros and Big Pharma at the St. Petersburg International Economic Forum — straight to the gulag for some desperately needed rehabilitation.

And of course, no Big Pharma smackdown would be complete without frog-marching Madame Arbidol to the most remote Siberian penal colony. Sorry, we don’t make the rules.

Edward SlavsquatRussia’s selfless COVID-pill profiteers: Heroes of public healthNine out of ten doctors agree: in order to survive cold-like symptoms, sometimes it is necessary to permanently damage your internal organs with antiviral drugs. This is what makes COVID so harrowing. The virus forces people to take life-ending medications…Read more23 days ago · 52 likes · 44 comments · Edward Slavsquat

Russia’s largest pharmaceutical firms also need to be put in the crosshairs. As we saw with Sputnik V, Russian drug companies enthusiastically collaborate with western pharmaceuticals to create horrific poisons for the masses. And the Russian government is invested in this gross cooperation — which is slightly discouraging?

Furthermore, the worst medicine-related grifting involves government contracts. And also: a lot of the pill peddling and unethical contracting is done legally.

As Tsargrad explained in an articleunpacking Putin’s comments:

Putin demanded action against Western pharmaceutical companies that bribe our doctors. Tsargrad examined the problem and found out that this bribery is most often completely legal. To change the situation, you need to change the laws. […]

The peculiarity of Russia lies in the active participation of the state in the market of medical services. It is more profitable to get a big contract and relax than to work painstakingly with doctors, although this is not neglected either. Therefore, our “favorite” form of illegal cooperation of pharmaceutical companies with the heads of institutions and officials is to ensure victory in the auction.

So, for example, at the end of 2019, the head doctor of the republican oncological dispensary of the Ministry of Health of the Republic of North Ossetia-Alania was caught red-handed while receiving a bribe on an especially large scale. A few days before that, the head physician of the Penza Regional Oncology Center (and soon the director of the pharmaceutical company who gave him a bribe) received five years of a real term. There are other precedents, many of them. […]

Of course, the problem raised by Chikhanchin and Putin concerns not only Western companies — the domestic pharmaceutical industry has adopted the worst habits of its “big brothers” and interacts with medical personnel no less successfully.

That sums up the situation pretty well, we think. 

We welcome any and all efforts to make Russian healthcare less scammy and more healthy. 

But let’s not forget that after two years of “public health measures” — two years of non-stop grifting and murderous lies — Russia now finds itself in a very, very deep hole — a hole dug by the Russian government. Go figure.

A population decline of more than 1 million people in 2021. The largest decline in decades. (source)

We should add that there are rumors on the Russian interwebz that several high ranking officials are under investigation as part of this alleged Big Pharma crackdown. We haven’t found anything substantial to support this claim but… fingers crossed?

Let’s see what the FSB cooks up. It’s 2022. Anything is possible. Even atonement.

URGENT UPDATE!

We have an update to share from the people health alliance

We have received info this morning from a government source, that suggest the government will be bringing back the masks in approx two weeks and are preparing for civil unrest. At this moment, we have no reason to think this untrue, and the source is trusted.

In response, the core team are keen to ensure the messaging we now use keeps everything calm and the vibration high. Mass peaceful non-compliance is absolutely key. Gov would love to see unrest and violence spill out onto our streets so they can try and ‘increase security for our safety and bring in greater restrictions and visible control, so how we move forward over the next two weeks is critical to get right.

Peaceful mass non-compliance is what THEY can’t handle. They’ve got nowhere to go with it. There’s nothing they can do. But there are still many out there who will feel angry, resentful and reactive. It is up to us, and other groups across the U.K., to ensure we keep moving forward with building the new and peaceful refusal to comply. We must not allow this to play into gov hands. There are so many of us now that the gov can’t win this, but we all must stand firm in our actions and beliefs and continue to support those around us who may feel wobbly or reactive.

We have had word that Tesco have started putting up new mask stickers and we’ve no doubt other large organisations have been instructed to do the same so seems like this will roll out very quickly. This insinuates they are panicking, so it’s never been more important that PHA lead by example by staying in a place of calm positivity. The gov have nothing but are now in their death throes and will chuck what it can at us. Let them. Ignore them. Focus on those around you who are feeling the negativity and let’s make it our aim to focus that energy on achieving something positive in their local community.

Now is a time to show the world our unity and strength. Now is the time to reach those on the fence and show them there’s an incredible and powerful way to take action – Community Compassion and positive action. Gone are the days when the media and other nefarious agencies get to dictate the narrative. Counter at every move, all over social media, in your own conversations, stick our stickers on their stickers, posters out in your community, actions YOU take. Make them positive. Make them empowering. Make them about ignoring the morons in gov, and about building the new and caring for each other.

Let’s do this. Let’s end this war. And let’s do it with the biggest of smiles.

As we head into the eye of the storm, we must remember why we are here, why we are the ones who have been awakened and have been getting prepared for this moment. We have the power to help lead our fellow people into a space of power, peace and prosperity. Gone are the days of old. We build the new and we build it together. We have the power to end this attack on us swiftly, effectively and peaceably. They will do all they can to stop us. But nothing can stop us from coming. Nothing. There are too many of us now. Let’s make sure we do this OUR way. Not be thrown into panic or fear because of the threats they make or actions they take. They’ve got nothing. We’ve got everything. Let’s just help those who do feel the fear to find a way through it without violence or negativity. Let’s shine our light brighter than ever before and keep it simple. Ignore them. Peaceful mass noncompliance is the way forward.

EXCITING ANNOUNCEMENT!!

PHA is going to be a sibling!!!

We are pleased to announce a new birth is due very soon… the People’s Food & Farming Alliance!!!

With food shortages incoming, an agricultural system that has been attacked for many years now, unhealthy food abound and an increasingly destructive impact on our natural world, the way we grow food and the practical production of food, needs to be changed. And it needs to be changed now.

Over the coming weeks, we will deliver our Community Food Growth Blueprint, along with practical plans, HUGE amounts of information and educational material, as well as guidance from some incredible experts.

In true People’s Alliance style, we are teaming up with other partners across the U.K. to secure our food future, bring stability and health back to our products and ensure we remove the toxic forces currently controlling Bigg by making them irrelevant. Our plans involve removing all the middlemen and taking back control of our food and ecosystems.

We ask you to kindly spread the word and keep your eyes peeled for important updates.

This takes all of us. The incoming harvest for autumn/winter 2023 looks dire. We HAVE to take back our power and make the urgent changes needed to ensure our smooth transition into a new world, whilst we not only survive, but we thrive.

None of what we do is tricky, it’s all very simple, but we can and must do this together.

We want to thank each and every one of you for the support you show PHA every single day. We are already bringing change and we are only TWO MONTHS old today! Who knows where we will be in six months, but every day we make a difference so we think all of us together will make this movement profound and successful. Thanks again, and we look forward to bringing PFFA to We The People over the next few weeks.


THE European Union just can’t get enough sanctions against Russia.

THE European Union just can’t get enough of sanctions against Russia. Several member governments arepushing for a whole new package in addition to increased military support for Kyiv. This will be Sanctions Round Seven.

Not all the EU nations are so gung-ho. Germany would prefer getting more out of the sanctions already in place. Then there’s the sensitive business of how the oil- and gas-guzzling members are going to cope with their self-inflicted ‘half rations’. Their newly drafted proposals include a definite commitment to military and financial support. Sweden and Poland are pressing for immediate disbursement of additional funds to Ukraine, drawn from the EU’s ironically named ‘European Peace Facility. Even this makes Germany a bit nervous.

As well it might, since the gas supply crisis is already exacerbated by the rise in the price of imported coal from a pre-conflict $80 per ton to over $330; at the same time, Green parties throughout the EU see their climate goals compromised by the re-opening of notoriously polluting brown coal mines. Hungarian PM Viktor Orban has rejected EU criticisms of his divergent nationally protective energy policy as being ‘supportive of Putin’, stating that the sustainability of Hungary’s economy is also in the interests of the EU.

From a policy intended to unite its members more closely and facilitate further eastward expansion, Brussels finds itself instead confronted by internal bickering and outright policy rejection. You have to wonder if the EU understands what it’s doing, particularly since the revelation that it has been pressing Lithuania – a member of the EU and Nato – to institute an effective blockade of the Russian exclave Kaliningrad.

The Kaliningrad region historically belonged to East Prussia. It was annexed by the Soviet Union after WW2, although since the independence of the Baltic States it has been physically separated from the Russian mainland. You can see a map here. The Suwalki Corridor, a 71-mile land border between Lithuania and Poland, connects Kaliningrad with Belarus, a staunch Russian ally, and is protected as a communications corridor between Russia and its exclave by the 2002 Joint Statement of the Russian Federation and the EU.

Kaliningrad’s geostrategic location has always been regarded as a potential flashpoint. It enables Russia to maintain its Baltic Fleet bases, allowing control over the Baltic Sea region and access to the Gulf of Finland, while at the same time restricting Nato access to the same, and affecting the potential security of Sweden and Finland. Memories in this region are long, and old conflicts are easily resurrected. At this time of outright conflict and relentless provocations, any move affecting the security of Russian territory can easily be seen as pushing Russia towards the last line of escalation.

Now that Lithuania has blocked vital deliveries of coal, metals and construction and technology materials from reaching Kaliningrad, Moscow has taken the bait, vowing never to trust the West again. For its part, Lithuania claims it is only ‘obeying orders’ by following the EU sanctions rule to which it is pledged. But to Moscow, this could well be the last straw. When retired general Evgeny Buzhinsky was asked ‘Is this a war with Nato?’ he replied, ‘Yes – what else do we do? Otherwise they’ll simply strangle us. We can’t stop, otherwise, they’ll deprive us of Kaliningrad.’ He sees ulterior motives in the development. ‘This is a long game to push us out of the Baltic, and attempt to block and cut off Kaliningrad, and finally take it away from us.’

While contact can be maintained via sea transport, Russian State television has warned that the attempt to isolate the region is – from the point of view of international law – a casus belli, a formal reason to declare war. (Latin-loving PM Boris Johnson should have no difficulty in understanding the implications of this.) General Buzhinsky has already called on President Putin to dispatch nuclear weapons.

Is Brussels genuinely up for this? In his book Flashpoints, George Friedman emphasises the keg-of-powder vulnerability of these regions, especially regarding Putin as Russian President and Nato as the only opposing military force of any potential.

US and European policies have worked consistently, since the fall of the Soviet Union, to turn former Soviet Republics into constitutional democracies, and have had success in the Baltic states and other Eastern European new members. This, claims Friedman, was always ideological rather than military. Putin, on the other hand, is a former KGB man, and his worldview is one of ruthless realism but little ideology. He has a deep loyalty to the state and a commitment to his country. ‘Intelligence people are cynical by nature . . . but they have not taken civil service jobs with mediocre pay and, for some, potential personal risk because they see this as a path to wealth and glory. Wealth doesn’t come with the job, and glory is rare in a life invisible to the world. Underneath everything is a patriotism coupled with deep professional pride that makes losing unbearable.’

Friedman believes that under Putin, Russia is looking to secure itself, not expand. In trying to expand, it would be faced with the potential power of Nato and the EU. However, he sees Nato as a shadow of its former self and constrained by its requirement to operate by consensus. The EU he considers a shambles. Even so, he considers that Russia benefits as much from a genuinely neutral buffer zone as from outright occupation. It does not want to dominate the region overtly, but it does want to limit the powers of Nato in the East and wishes to limit further EU integration.

Finally, he emphasises that the Russians are inherently drawn west out of fear. It is difficult to defend Russia from the north, and Belarus is indispensable as a buffer. But the fear stems from the three small Baltic states, including Lithuania. The countries themselves are not the problem, it is their geography: ‘The Baltic States are a bayonet pointing at St Petersburg.’ They could be used as a base from which to attack Russia. Hence the crucial significance of holding on to Kaliningrad. ‘The Baltics are the one place where Russians cannot relax. This is the immediate flashpoint in the borderland between the peninsula and the mainland.’

While the US remains a willing supporter of the West’s position, through finance and military equipment, this conflict remains for it a proxy war, being waged until the last Ukrainian standing. No US boots on the ground. The American administration is content to see the EU and Russia bogged down by military and economic mayhem, preventing either from assuming a global role which could challenge the US hegemony.

So, for the EU to goad Putin into military action against a Nato country, triggering the US’s obligation to come to its military defence, is the behaviour of a potentially fragmenting political entity punching well above its weight.

The Times reports that the EU will attempt to de-escalate the dispute with Russia over Kaliningrad, citing senior diplomatic sources in Brussels. One was quoted as saying: ‘It is not a climbdown but is about avoiding an escalation. The EU is not trying to blockade Kaliningrad.’

Soeren Kern, senior fellow at the Gatestone Institute, writes that the EU, which was praised for displaying determination, unity and speed in its response to Putin, was said to be facing a transformative moment that would allow the bloc to become a geostrategic actor on the global stage. One observer is quoted as saying the EU had become a top geopolitical protagonist and had discovered that it is a superpower.

But as the war has dragged on, European unity has collapsed and these superstate ambitions have been exposed as delusions of grandeur. While France and Germany have sought to appease Putin at the expense of Ukrainian sovereignty by going to the negotiating table, and thus reserving effective trading activities, the Eastern states see mediation as a humiliation for them and Ukraine. The Latvian PM Arturs Karins has stated that ‘peace at any cost is what we have done for 20 years with Putin. Peace at any cost means Putin wins. We end up losing’. And according to John Sawers, former head of MI6, failing to uphold Ukrainian sovereignty leaves Russia empowered to launch new military adventures in the future, while the Swiss Neue Zürcher Zeitung reminds us that the only check on Russia remains US military strength, which means that Nato is more important for the free West than it has been for decades.

Has Brussels thought all this through, while at the same time facing a potential recession, threats to the euro’s stability, a commitment to massive post-conflict reconstruction costs, and an overly optimistic expectation of Nato/US willingness to be drawn actively into a third world war? Is it prepared to stand shoulder to shoulder with that iconic example of emerging constitutional democracy – Ukraine – while its President Zelensky has just banned the country’s main opposition party and seized all its assets while locking up its leader and threatening to round up other political dissenters?

Is this the ‘Beacon of Democracy’ that justifies a nuclear conflagration?

Treacherous Treatments:

🇺🇸 In America and the Uk 🇬🇧

Treacherous Treatments: These Hospitals Are Committing Battery and Murdering People

Backed by Fauci and NIH protocols, hospitals receive a 20% bonus on the entire patient bill when they prescribe Remdesivir.

– 25.7% death rate

– 29.8% kidney failure or sepsis rate

Attorney Thomas Renz: “This is a mind-blowingly high number, especially when they’re trying to attack ivermectin where you see no side effects.”

“People are saying, ‘Don’t give me Remdesivir,’ and they’re doing it anyway. That is a battery. That is a battery under about any law that I can think of … The hospital doesn’t have the right to force you into something you don’t want.”

This is so spot on.

Once it’s appreciated that government lies all the time, you realise the worst thing is to let them lie to you even more, in your house.

Do yourself a favour. Exclude these selfish, stupid & temporary politicians from your entire family’s life.

If you’ve not listened to me

If you’ve not listened to me, try someone who spent half a lifetime on the inside of the financial system.

There are no limits to the way they can bring pressure to bear on each of you. They can deny you & your family food. They can seize your kids.

Once a digital control system is in place, there’s no escape or recourse. It’ll all be legal since your parliament will pass the laws.

I need you to commit yourself to informing other people, people who don’t yet know what you know.

If you won’t even risk a little embarrassment, maybe someone shouting angrily, how will you resist the next coercive step along the road to hell?

Your neighbours are scared too, I assure you. That’s why they react with such extraordinary passion when you question their beliefs.

I need your help. You need your help.

Will you do it? And keep doing it?

If you won’t, do you expect me to continue?

If not you, who? If not now, when?

Unaccountable OLIGARCHS are pushing fake ‘green’ agendas

Unaccountable OLIGARCHS are pushing fake ‘green’ agendas in order to loot and stockpile Africa’s resources, destroying biomes and culling populations with ‘vaccinations’.

A video comparing the “green new promise” of renewable energy to the harsh realities on the ground, highlighting the West’s entrenched lack of respect in its relationship to African people and Environment.

Video 12 minutes in the link.

with Robin Monotti @robinmg

and Nick Hudson.

https://odysee.com/@FreedomTirade:f/STOP-OLIGARCHS:5

The Glencore corporation was recently fined > $1.1 billion by the US Securities and Exchange Commission for looting and corrupting Africa.

Will Africa receive any compensation?

No.

The money REMAINS with the US SEC which oversees the looting of Africa

Only when we extoll the virtues of ethics above profit…

Only when we take back responsibility for our own health,

Only then will we change Healthcare,

and the World for the Better.

WE ARE ALL JULIAN ASSANGE

COVID UPDATE: What is the truth?

Russell L. Blaylock
Additional article information

Russell L. Blaylock

The COVID-19 pandemic is one of the most manipulated infectious disease events in history, characterized by official lies in an unending stream lead by government bureaucracies, medical associations, medical boards, the media, and international agencies.[3,6,57] We have witnessed a long list of unprecedented intrusions into medical practice, including attacks on medical experts, destruction of medical careers among doctors refusing to participate in killing their patients and a massive regimentation of health care, led by non-qualified individuals with enormous wealth, power and influence.

For the first time in American history a president, governors, mayors, hospital administrators and federal bureaucrats are determining medical treatments based not on accurate scientifically based or even experience based information, but rather to force the acceptance of special forms of care and “prevention”—including remdesivir, use of respirators and ultimately a series of essentially untested messenger RNA vaccines. For the first time in history medical treatment, protocols are not being formulated based on the experience of the physicians treating the largest number of patients successfully, but rather individuals and bureaucracies that have never treated a single patient—including Anthony Fauci, Bill Gates, EcoHealth Alliance, the CDC, WHO, state public health officers and hospital administrators.[23,38]

The media (TV, newspapers, magazines, etc), medical societies, state medical boards and the owners of social media have appointed themselves to be the sole source of information concerning this so-called “pandemic”. Websites have been removed, highly credentialed and experienced clinical doctors and scientific experts in the field of infectious diseases have been demonized, careers have been destroyed and all dissenting information has been labeled “misinformation” and “dangerous lies”, even when sourced from top experts in the fields of virology, infectious diseases, pulmonary critical care, and epidemiology. These blackouts of truth occur even when this information is backed by extensive scientific citations from some of the most qualified medical specialists in the world.[23] Incredibly, even individuals, such as Dr. Michael Yeadon, a retired ex-Chief Scientist, and vice-president for the science division of Pfizer Pharmaceutical company in the UK, who charged the company with making an extremely dangerous vaccine, is ignored and demonized. Further, he, along with other highly qualified scientists have stated that no one should take this vaccine.

Dr. Peter McCullough, one of the most cited experts in his field, who has successfully treated over 2000 COVID patients by using a protocol of early treatment (which the so-called experts completely ignored), has been the victim of a particularly vicious assault by those benefiting financially from the vaccines. He has published his results in peer reviewed journals, reporting an 80% reduction in hospitalizations and a 75% reduction in deaths by using early treatment.[44] Despite this, he is under an unrelenting series of attacks by the information controllers, none of which have treated a single patient.

Neither Anthony Fauci, the CDC, WHO nor any medical governmental establishment has ever offered any early treatment other than Tylenol, hydration and call an ambulance once you have difficulty breathing. This is unprecedented in the entire history of medical care as early treatment of infections is critical to saving lives and preventing severe complications. Not only have these medical organizations and federal lapdogs not even suggested early treatment, they attacked anyone who attempted to initiate such treatment with all the weapons at their disposal—loss of license, removal of hospital privileges, shaming, destruction of reputations and even arrest.[2]

A good example of this outrage against freedom of speech and providing informed consent information is the recent suspension by the medical board in Maine of Dr. Meryl Nass’ medical license and the ordering of her to undergo a psychiatric evaluation for prescribing Ivermectin and sharing her expertise in this field.[9,65] I know Dr, Nass personally and can vouch for her integrity, brilliance and dedication to truth. Her scientific credentials are impeccable. This behavior by a medical licensing board is reminiscent of the methodology of the Soviet KGB during the period when dissidents were incarcerated in psychiatric gulags to silence their dissent.

OTHER UNPRECEDENTED ATTACKS

Another unprecedented tactic is to remove dissenting doctors from their positions as journal editors, reviewers and retracting of their scientific papers from journals, even after these papers have been in print. Until this pandemic event, I have never seen so many journal papers being retracted— the vast majority promoting alternatives to official dogma, especially if the papers question vaccine safety. Normally a submitted paper or study is reviewed by experts in the field, called peer review. These reviews can be quite intense and nit picking in detail, insisting that all errors within the paper be corrected before publication. So, unless fraud or some other major hidden problem is discovered after the paper is in print, the paper remains in the scientific literature.

We are now witnessing a growing number of excellent scientific papers, written by top experts in the field, being retracted from major medical and scientific journals weeks, months and even years after publication. A careful review indicates that in far too many instances the authors dared question accepted dogma by the controllers of scientific publications—especially concerning the safety, alternative treatments or efficacy of vaccines.[12,63] These journals rely on extensive adverting by pharmaceutical companies for their revenue. Several instances have occurred where powerful pharmaceutical companies exerted their influence on owners of these journals to remove articles that in any way question these companies’ products.[13,34,35]

Worse still is the actual designing of medical articles for promoting drugs and pharmaceutical products that involve fake studies, so-called ghostwritten articles.[49,64] Richard Horton is quoted by the Guardian as saying “journals have devolved into information laundering operations for the pharmaceutical industry.”[13,63] Proven fraudulent “ghostwritten” articles sponsored by pharmaceutical giants have appeared regularly in top clinical journals, such as JAMA, and New England Journal of Medicine—never to be removed despite proven scientific abuse and manipulation of data.[49,63]

Ghostwritten articles involve using planning companies whose job it is to design articles containing manipulated data to support a pharmaceutical product and then have these articles accepted by high-impact clinical journals, that is, the journals most likely to affect clinical decision making of doctors. Further, they supply doctors in clinical practice with free reprints of these manipulated articles. The Guardian found 250 companies engaged in this ghostwriting business. The final step in designing these articles for publication in the most prestigious journals is to recruit well recognized medical experts from prestigious institutions, to add their name to these articles. These recruited medical authors are either paid upon agreeing to add their name to these pre- written articles or they do so for the prestige of having their name on an article in a prestigious medical journal.[11]

Of vital importance is the observation by experts in the field of medical publishing that nothing has been done to stop this abuse. Medical ethicists have lamented that because of this widespread practice “you can’t trust anything.” While some journals insist on disclosure information, most doctors reading these articles ignore this information or excuse it and several journals make disclosure more difficult by requiring the reader to find the disclosure statements at another location. Many journals do not police such statements and omissions by authors are common and without punishment.

As concerns the information made available to the public, virtually all the media is under the control of these pharmaceutical giants or others who are benefitting from this “pandemic”. Their stories are all the same, both in content and even wording. Orchestrated coverups occur daily and massive data exposing the lies being generated by these information controllers are hidden from the public. All data coming over the national media (TV, newspaper and magazines), as well as the local news you watch every day, comes only from “official” sources—most of which are lies, distortions or completely manufactured out of whole cloth—all aimed to deceive the public.

Television media receives the majority of its advertising budget from the international pharmaceutical companies—this creates an irresistible influence to report all concocted studies supporting their vaccines and other so-called treatments.[14] In 2020 alone the pharmaceutical industries spent 6.56 billion dollars on such advertising.[13,14] Pharma TV advertising amounted to 4.58 billion, an incredible 75% of their budget. That buys a lot of influence and control over the media. World famous experts within all fields of infectious diseases are excluded from media exposure and from social media should they in any way deviate against the concocted lies and distortions by the makers of these vaccines. In addition, these pharmaceutical companies spend tens of millions on social media advertising, with Pfizer leading the pack with $55 million in 2020.[14]

While these attacks on free speech are terrifying enough, even worse is the virtually universal control hospital administrators have exercised over the details of medical care in hospitals. These hirelings are now instructing doctors which treatment protocols they will adhere to and which treatments they will not use, no matter how harmful the “approved” treatments are or how beneficial the “unapproved” treatments are.[33,57]

Never in the history of American medicine have hospital administrators dictated to its physicians how they will practice medicine and what medications they can use. The CDC has no authority to dictate to hospitals or doctors concerning medical treatments. Yet, most physicians complied without the slightest resistance.

The federal Care Act encouraged this human disaster by offering all US hospitals up to 39,000 dollars for each ICU patient they put on respirators, despite the fact that early on it was obvious that the respirators were a major cause of death among these unsuspecting, trusting patients. In addition, the hospitals received 12,000 dollars for each patient that was admitted to the ICU—explaining, in my opinion and others, why all federal medical bureaucracies (CDC, FDA, NIAID, NIH, etc) did all in their power to prevent life- saving early treatments.[46] Letting patients deteriorate to the point they needed hospitalization, meant big money for all hospitals. A growing number of hospitals are in danger of bankruptcy, and many have closed their doors, even before this “pandemic”.[50] Most of these hospitals are now owned by national or international corporations, including teaching hospitals.[10]

It is also interesting to note that with the arrival of this “pandemic” we have witnessed a surge in hospital corporate chains buying up a number of these financially at-risk hospitals.[1,54] It has been noted that billions in Federal Covid aid is being used by these hospital giants to acquire these financially endangered hospitals, further increasing the power of corporate medicine over physician independence. Physicians expelled from their hospitals are finding it difficult to find other hospitals staffs to join since they too may be owned by the same corporate giant. As a result, vaccine mandate policies include far larger numbers of hospital employees. For example, Mayo Clinic fired 700 employees for exercising their right to refuse a dangerous, essentially untested experimental vaccine.[51,57] Mayo Clinic did this despite the fact that many of these employees worked during the worst of the epidemic and are being fired when the Omicron variant is the dominant strain of the virus, has the pathogenicity of a common cold for most and the vaccines are ineffective in preventing the infection.

In addition, it has been proven that the vaccinated asymptomatic person has a nasopharyngeal titer of the virus as high as an infected unvaccinated person. If the purpose of the vaccine mandate is to prevent viral spread among the hospital staff and patients, then it is the vaccinated who present the greatest risk of transmission, not the unvaccinated. The difference is that a sick unvaccinated person would not go to work, the asymptomatic vaccinated spreader will.

What we do know is that major medical centers, such as Mayo Clinic, receive tens of millions of dollars in NIH grants each year as well as monies from the pharmaceutical makers of these experimental “vaccines”. In my view, that is the real consideration driving these policies. If this could be proven in a court of law the administrators making these mandates should be prosecuted to the fullest extent of the law and sued by all injured parties.

The hospital bankruptcy problem has grown increasingly acute due to hospitals vaccine mandates and resulting large number of hospitals staff, especially nurses, refusing to be forcibly vaccinated.[17,51] This is all unprecedented in the history of medical care. Doctors within hospitals are responsible for the treatment of their individual patients and work directly with these patients and their families to initiate these treatments. Outside organizations, such as the CDC, have no authority to intervene in these treatments and to do so exposes the patients to grave errors by an organization that has never treated a single COVID-19 patient.

When this pandemic started, hospitals were ordered by the CDC to follow a treatment protocol that resulted in the deaths of hundreds of thousands of patients, most of whom would have recovered had proper treatments been allowed.[43,44] The majority of these deaths could have been prevented had doctors been allowed to use early treatment with such products as Ivermectin, hydroxy-chloroquine and a number of other safe drugs and natural compounds. It has been estimated, based on results by physicians treating the most covid patients successfully, that of the 800,000 people that we are told died from Covid, 640,000 could have not only been saved, but could have, in many cases, returned to their pre-infection health status had mandated early treatment with these proven methods been used. This neglect of early treatment constitutes mass murder. That means 160,000 would have actually died, far less than the number dying at the hands of bureaucracies, medical associations and medical boards that refused to stand up for their patients. According to studies of early treatment of thousands of patients by brave, caring doctors, seventy-five to eighty percent of the deaths could have been prevented.[43,44]

Incredibly, these knowledgeable doctors were prevented from saving these Covid-19 infected people. It should be an embarrassment to the medical profession that so many doctors mindlessly followed the deadly protocols established by the controllers of medicine.

One must also keep in mind that this event never satisfied the criteria for a pandemic. The World Health Organization changed the criteria to make this a pandemic. To qualify for a pandemic status the virus must have a high mortality rate for the vast majority of people, which it didn’t (with a 99.98% survival rate), and it must have no known existing treatments—which this virus had—in fact, a growing number of very successful treatments.

The draconian measures established to contain this contrived “pandemic” have never been shown to be successful, such as masking the public, lockdowns, and social distancing. A number of carefully done studies during previous flu seasons demonstrated that masks, of any kind, had never prevented the spread of the virus among the public.[60]

In fact, some very good studies suggested that the masks actually spread the virus by giving people a false sense of security and other factors, such as the observation that people were constantly breaking sterile technique by touching their mask, improper removal and by leakage of infectious aerosols around the edges of the mask. In addition masks were being disposed of in parking lots, walking trails, laid on tabletops in restaurants and placed in pockets and purses.

Within a few minutes of putting on the mask, a number of pathogenic bacteria can be cultured from the masks, putting the immune suppressed person at a high risk of bacterial pneumonia and children at a higher risk of meningitis.[16] A study by researchers at the University of Florida cultured over 11 pathogenic bacteria from the inside of the mask worn by children in schools.[40]

It was also known that children were at essentially no risk of either getting sick from the virus or transmitting it.

In addition, it was also known that wearing a mask for over 4 hours (as occurs in all schools) results in significant hypoxia (low blood oxygen levels) and hypercapnia (high CO2 levels), which have a number of deleterious effects on health, including impairing the development of the child’s brain.[4,72,52]

We have known that brain development continues long after the grade school years. A recent study found that children born during the “pandemic” have significantly lower IQs—yet school boards, school principals and other educational bureaucrats are obviously unconcerned.[18]

TOOLS OF THE INDOCTRINATION TRADE

The designers of this pandemic anticipated a pushback by the public and that major embarrassing questions would be asked. To prevent this, the controllers fed the media a number of tactics, one of the most commonly used was and is the “fact check” scam. With each confrontation with carefully documented evidence, the media “fact checkers” countered with the charge of “misinformation”, and an unfounded “conspiracy theory” charge that was, in their lexicon, “debunked”. Never were we told who the fact checkers were or the source of their “debunking” information—we were just to believe the “fact checkers”. A recent court case established under oath that facebook “fact checkers” used their own staff opinion and not real experts to check “facts”.[59] When sources are in fact revealed they are invariably the corrupt CDC, WHO or Anthony Fauci or just their opinion. Here is a list of things that were labeled as “myths” and “misinformation” that were later proven to be true.

  • The asymptomatic vaccinated are spreading the virus equally as with unvaccinated symptomatic infected.
  • The vaccines cannot protect adequately against new variants, such as Delta and Omicron.
  • Natural immunity is far superior to vaccine immunity and is most likely lifelong.
  • Vaccine immunity not only wanes after several months, but all immune cells are impaired for prolonged periods, putting the vaccinated at a high risk of all infections and cancer.
  • COVID vaccines can cause a significant incidence of blood clots and other serious side effects
  • The vaccine proponents will demand numerous boosters as each variant appears on the scene.
  • Fauci will insist on the covid vaccine for small children and even babies.
  • Vaccine passports will be required to enter a business, fly in a plane, and use public transportation
  • There will be internment camps for the unvaccinated (as in Australia, Austria and Canada)
  • The unvaccinated will be denied employment.
  • There are secret agreements between the government, elitist institutions, and vaccine makers
  • Many hospitals were either empty or had low occupancy during the pandemic.
  • The spike protein from the vaccine enters the nucleus of the cell, altering cell DNA repair function.
  • Hundreds of thousands have been killed by the vaccines and many times more have been permanently damaged.
  • Early treatment could have saved the lives of most of the 700,000 who died.
  • Vaccine-induced myocarditis (which was denied initially) is a significant problem and clears over a short period.
  • Special deadly lots (batches) of these vaccines are mixed with the mass of other Covid-19 vaccines

Several of these claims by those opposing these vaccines now appear on the CDC website—most still identified as “myths”. Today, extensive evidence has confirmed that each of these so-called “myths” were in fact true. Many are even admitted by the “saint of vaccines”, Anthony Fauci. For example, we were told, even by our cognitively impaired President, that once the vaccine was released all the vaccinated people could take off their masks. Oops! We were told shortly afterward— the vaccinated have high concentrations (titers) of the virus in their noses and mouths (nasopharynx) and can transmit the virus to others in which they come into contact—especially their own family members. On go the masks once again— in fact double masking is recommended. The vaccinated are now known to be the main superspreaders of the virus and hospitals are filled with the sick vaccinated and people suffering from serious vaccine complications.[27,42,45]

Another tactic by the vaccine proponents is to demonize those who reject being vaccinated for a variety of reasons. The media refers to these critically thinking individuals as “anti-vaxxers”, “vaccine deniers”, “Vaccine resisters”, “murders”, “enemies of the greater good” and as being the ones prolonging the pandemic. I have been appalled by the vicious, often heartless attacks by some of the people on social media when a parent or loved one relates a story of the terrible suffering and eventual death, they or their loved one suffered as a result of the vaccines. Some psychopaths tweet that they are glad that the loved one died or that the dead vaccinated person was an enemy of good for telling of the event and should be banned. This is hard to conceptualize. This level of cruelty is terrifying, and signifies the collapse of a moral, decent, and compassionate society.

It is bad enough for the public to sink this low, but the media, political leaders, hospital administrators, medical associations and medical licensing boards are acting in a similar morally dysfunctional and cruel way.

LOGIC, REASONING, AND SCIENTIFIC EVIDENCE HAS DISAPPEARED IN THIS EVENT

Has scientific evidence, carefully done studies, clinical experience and medical logic had any effect on stopping these ineffective and dangerous vaccines? Absolutely not! The draconian efforts to vaccinate everyone on the planet continues (except the elite, postal workers, members of Congress and other insiders).[31,62]

In the case of all other drugs and previous conventional vaccines under review by the FDA, the otherwise unexplained deaths of 50 or less individuals would result in a halt in further distribution of the product, as happened on 1976 with the swine flu vaccine. With over 18,000 deaths being reported by the VAERS system for the period December 14, 2020 and December 31st, 2021 as well as 139,126 serious injuries (including deaths) for the same period there is still no interest in stopping this deadly vaccine program.[61] Worse, there is no serious investigation by any government agency to determine why these people are dying and being seriously and permanently injured by these vaccines.[15,67] What we do see is a continuous series of coverups and evasions by the vaccine makers and their promoters.

The war against effective cheap and very safe repurposed drugs and natural compounds, that have proven beyond all doubt to have saved millions of lives all over the world, has not only continued but has stepped up in intensity.[32,34,43]

Doctors are told they cannot provide these life-saving compounds for their patients and if they do, they will be removed from the hospital, have their medical license removed or be punished in many other ways. A great many pharmacies have refused to fill prescriptions for lvermectin or hydroxy- chloroquine, despite the fact that millions of people have taken these drugs safely for over 60 years in the case of hydroxy chloroquine and decades for Ivermectin.[33,36] This refusal to fill prescriptions is unprecedented and has been engineered by those wanting to prevent alternative methods of treatment, all based on protecting vaccine expansion to all. Several companies that make hydroxy chloroquine agreed to empty their stocks of the drug by donating them to the Strategic National Stockpile, making this drug far more difficult to get.[33] Why would the government do that when over 30 well-done studies have shown that this drug reduced deaths anywhere from 66% to 92% in other countries, such as India, Egypt, Argentina, France, Nigeria, Spain, Peru, Mexico, and others?[23]

The critics of these two life-saving drugs are most often funded by Bill Gates and Anthony Fauci, both of which are making millions from these vaccines.[48,15]

To further stop the use of these drugs, the pharmaceutical industry and Bill Gates/Anthony Fauci funded fake research to make the case that hydroxy chloroquine was a dangerous drug and could damage the heart.[34] To make this fraudulent case the researchers administered the sickest of covid patients a near lethal dose of the drug, in a dose far higher than used on any covid patient by Dr. Kory, McCullough and other “real”, and compassionate doctors, physicians who were actually treating covid patients.[23]

The controlled, lap-dog media, of course, hammered the public with stories of the deadly effect of hydroxy- chloroquine, all with a terrified look of fake panic. All these stories of ivermectin dangers were shown to be untrue and some of the stories were incredibly preposterous.[37,43]

The attack on Ivermectin was even more vicious than against hydroxy-chloroquine. All of this, and a great deal more is meticulously chronicled in Robert Kennedy, Jr’s excellent new book—The Real Anthony Fauci. Bill Gates, Big Pharma, and the Global War on Democracy and Public Health.[32] If you are truly concerned with the truth and with all that has occurred since this atrocity started, you must not only read, but study this book carefully. It is fully referenced and covers all topics in great detail. This is a designed human tragedy of Biblical proportions by some of the most vile, heartless, psychopaths in history.

Millions have been deliberately killed and crippled, not only by this engineered virus, but by the vaccine itself and by the draconian measures used by these governments to “control the pandemic spread”. We must not ignore the “deaths by despair” caused by these draconian measures, which can exceed hundreds of thousands. Millions have starved in third world countries as a result. In the United States alone, of the 800,000 who died, claimed by the medical bureaucracies, well over 600,000 of these deaths were the result of the purposeful neglect of early treatment, blocking the use of highly effective and safe repurposed drugs, such as hydroxy-chloroquine and Ivermectin, and the forced use of deadly treatments such as remdesivir and use of ventilators. This does not count the deaths of despair and neglected medical care caused by the lockdown and hospital measures forced on healthcare systems.

To compound all this, because of vaccine mandates among all hospital personnel, thousands of nurses and other hospital workers have resigned or been fired.[17,30,51] This has resulted in critical shortages of these vital healthcare workers and dangerous reductions of ICU beds in many hospitals. In addition, as occurred in the Lewis County Healthcare System, a specialty-hospital system in Lowville, N.Y., closed its maternity unit following the resignation of 30 hospital staff over the state’s disastrous vaccine mandate orders. The irony in all these cases of resignations is that the administrators unhesitatingly accepted these mass staffing losses despite rantings about suffering from short staffing during a “crisis”. This is especially puzzling when we learned that the vaccines did not prevent viral transmission and the present predominant variant is of extremely low pathogenicity.

DANGERS OF THE VACCINES ARE INCREASINGLY REVEALED BY SCIENCE

While most researchers, virologists, infectious disease researchers and epidemiologists have been intimidated into silence, a growing number of high integrity individuals with tremendous expertise have come forward to tell the truth—that is, that these vaccines are deadly.

Most new vaccines must go through extensive safety testing for years before they are approved. New technologies, such as the mRNA and DNA vaccines, require a minimum of 10 years of careful testing and extensive follow-up. These new so-called vaccines were “tested” for only 2 months and then the results of these safety test were and continue to be kept secret. Testimony before Senator Ron Johnson by several who participated in the 2 months study indicates that virtually no follow-up of the participants of the pre-release study was ever done.[67] Complains of complications were ignored and despite promises by Pfizer that all medical expenses caused by the “vaccines” would be paid by Pfizer, these individuals stated that none were paid.[66] Some medical expenses exceed 100,000 dollars.

As an example of the deception by Pfizer, and the other makers of mRNA vaccines, is the case of 12-year-old Maddie de Garay, who participated in the Pfizer vaccine pre-release safety study. At Sen. Johnson’s presentation with the families of the vaccine injured, her mother told of her child’s recurrent seizures, that she is now confined to a wheelchair, must be tube fed and suffers permanent brain damage. On the Pfizer safety evaluation submitted to the FDA her only side effect is listed as having a “stomachache”. Each person submitted similar horrifying stories.

The Japanese resorted to a FOIA (Freedom of Information Act) lawsuit to force Pfizer to release its secret biodistribution study. The reason Pfizer wanted it kept secret is that it demonstrated that Pfizer lied to the public and the regulatory agencies about the fate of the injected vaccine contents (the mRNA enclosed nano-lipid carrier). They claimed that it remained at the site of the injection (the shoulder), when in fact their own study found that it rapidly spread throughout the entire body by the bloodstream within 48 hours.

The study also found that these deadly nano-lipid carriers collected in very high concentrations in several organs, including the reproductive organs of males and females, the heart, the liver, the bone marrow, and the spleen (a major immune organ). The highest concentration was in the ovaries and the bone marrow. These nano-lipid carriers also were deposited in the brain.

Dr. Ryan Cole, a pathologist from Idaho reported a dramatic spike in highly aggressive cancers among vaccinated individuals, (not reported in the Media). He found a frighteningly high incidence of highly aggressive cancers in vaccinated individuals, especially highly invasive melanomas in young people and uterine cancers in women.[26] Other reports of activation of previously controlled cancers are also appearing among vaccinated cancer patients.[47] Thus far, no studies have been done to confirm these reports, but it is unlikely such studies will be done, at least studies funded by grants from the NIH.

The high concentration of spike proteins found in the ovaries in the biodistribution study could very well impair fertility in young women, alter menstruation, and could put them at an increased risk of ovarian cancer. The high concentration in the bone marrow, could also put the vaccinated at a high risk of leukemia and lymphoma. The leukemia risk is very worrisome now that they have started vaccinating children as young as 5 years of age. No long-term studies have been conducted by any of these makers of Covid-19 vaccines, especially as regards the risk of cancer induction. Chronic inflammation is intimately linked to cancer induction, growth and invasion and vaccines stimulate inflammation.

Cancer patients are being told they should get vaccinated with these deadly vaccines. This, in my opinion, is insane. Newer studies have shown that this type of vaccine inserts the spike protein within the nucleus of the immune cells (and most likely many cell types) and once there, inhibits two very important DNA repair enzymes, BRCA1 and 53BP1, whose duty it is to repair damage to the cell’s DNA.[29] Unrepaired DNA damage plays a major role in cancer.

There is a hereditary disease called xeroderma pigmentosum in which the DNA repair enzymes are defective. These ill-fated individuals develop multiple skin cancers and a very high incidence of organ cancer as a result. Here we have a vaccine that does the same thing, but to a less extensive degree.

One of the defective repair enzymes caused by these vaccines is called BRCA1, which is associated with a significantly higher incidence of breast cancer in women and prostate cancer in men.

It should be noted that no studies were ever done on several critical aspects of this type of vaccine.

  • They have never been tested for long term effects
  • They have never been tested for induction of autoimmunity
  • They have never been properly tested for safety during any stage of pregnancy
  • No follow-up studies have been done on the babies of vaccinated women
  • There are no long-term studies on the children of vaccinated pregnant women after their birth (Especially as neurodevelopmental milestone occur).
  • It has never been tested for effects on a long list of medical conditions:
    • Diabetes
    • Heart disease
    • Atherosclerosis
    • Neurodegenerative diseases
    • Neuropsychiatric effects
    • Induction of autism spectrum disorders and schizophrenia
    • Long term immune function
    • Vertical transmission of defects and disorders
    • Cancer
    • Autoimmune disorders

Previous experience with the flu vaccines clearly demonstrates that the safety studies done by researchers and clinical doctors with ties to pharmaceutical companies were essentially all either poorly done or purposefully designed to falsely show safety and coverup side effects and complications. This was dramatically demonstrated with the previously mentioned phony studies designed to indicate that hydroxy Chloroquine and Ivermectin were ineffective and too dangerous to use.[34,36,37] These fake studies resulted in millions of deaths and severe health disasters worldwide. As stated, 80% of all deaths were unnecessary and could have been prevented with inexpensive, safe repurposed medications with a very long safety history among millions who have taken them for decades or even a lifetime.[43,44]

It is beyond ironic that those claiming that they are responsible for protecting our health approved a poorly tested set of vaccines that has resulted in more deaths in less than a year of use than all the other vaccines combined given over the past 30 years. Their excuse when confronted was—“we had to overlook some safety measures because this was a deadly pandemic”.[28,46]

In 1986 President Reagan signed the National Childhood Vaccine Injury Act, which gave blanket protection to pharmaceutical makers of vaccines against injury litigation by families of vaccine injured individuals. The Supreme Court, in a 57-page opinion, ruled in favor of the vaccine companies, effectively allowing vaccine makers to manufacture and distribute dangerous, often ineffective vaccines to the population without fear of legal consequences. The court did insist on a vaccine injury compensation system which has paid out only a very small number of rewards to a large number of severely injured individuals. It is known that it is very difficult to receive these awards. According to the Health Resources and Services Administration, since 1988 the Vaccine Injury Compensation Program (VICP) has agreed to pay 3,597 awards among 19,098 vaccine injured individuals applying amounting to a total sum of $3.8 billion. This was prior to the introduction of the Covid-19 vaccines, in which the deaths alone exceed all deaths related to all the vaccines combined over a thirty-year period.

In 2018 President Trump signed into law the “right-to-try” law which allowed the use of experimental drugs and all unconventional treatments to be used in cases of extreme medical conditions. As we have seen with the refusal of many hospitals and even blanket refusal by states to allow Ivermectin, hydroxy-chloroquine or any other unapproved “official” methods to treat even terminal Covid-19 cases, these nefarious individuals have ignored this law.

Strangely, they did not use this same logic or the law when it came to Ivermectin and Hydroxy Chloroquine, both of which had undergone extensive safety testing by over 30 clinical studies of a high quality and given glowing reports on both efficacy and safety in numerous countries. In addition, we had a record of use for up to 60 years by millions of people, using these drugs worldwide, with an excellent safety record. It was obvious that a group of very powerful people in conjunction with pharmaceutical conglomerates didn’t want the pandemic to end and wanted vaccines as the only treatment option. Kennedy’s book makes this case using extensive evidence and citations.[14,32]

Dr. James Thorpe, an expert in maternal-fetal medicine, demonstrates that these covoid-19 vaccines given during pregnancy have resulted in a 50-fold higher incidence of miscarriage than reported with all other vaccines combined.[28] When we examine his graph on fetal malformations there was a 144-fold higher incidence of fetal malformation with the Covid-19 vaccines given during pregnancy as compared to all other vaccines combined. Yet, the American Academy of Obstetrics and Gynecology and the American College of Obstetrics and Gynecology endorse the safety of these vaccines for all stages of pregnancy and among women breast feeding their babies.

It is noteworthy that these medical specialty groups have received significant funding from Pfizer pharmaceutical company. The American College of Obstetrics and Gynecology, just in the 4th quarter of 2010, received a total of $11,000 from Pfizer Pharmaceutical company alone.[70] Funding from NIH grants are much higher.[20] The best way to lose these grants is to criticize the source of the funds, their products or pet programs. Peter Duesberg, because of his daring to question Fauci’s pet theory of AIDS caused by HIV virus, was no longer awarded any of the 30 grant applications he submitted after going public. Prior to this episode, as the leading authority on retroviruses in the world, he had never been turned down for an NIH grant.[39] This is how the “corrupted” system works, even though much of the grant money comes from our taxes.

HOT LOTS—DEADLY BATCHES OF THE VACCINES

A new study has now surfaced, the results of which are terrifying.[25] A researcher at Kingston University in London, has completed an extensive analysis of the VAERs data (a subdepartment of the CDC which collects voluntary vaccine complication data), in which he grouped reported deaths following the vaccines according to the manufacturer’s lot numbers of the vaccines. Vaccines are manufactured in large batches called lots. What he discovered was that the vaccines are divided into over 20,000 lots and that one out of every 200 of these batches (lots) is demonstrably deadly to anyone who receives a vaccine from that lot, which includes thousands of vaccine doses.

He examined all manufactured vaccines—Pfizer, Moderna, Johnson and Johnson (Janssen), etc. He found that among every 200 batches of the vaccine from Pfizer and other makers, one batch of the 200 was found to be over 50x more deadly than vaccines batches from other lots. The other vaccine lots (batches) were also causing deaths and disabilities, but nowhere near to this extent. These deadly batches should have appeared randomly among all “vaccines” if it was an unintentional event. However, he found that 5% of the vaccines were responsible for 90% of the serious adverse events, including deaths. The incidence of deaths and serious complications among these “hot lots” varied from over 1000% to several thousand percent higher than comparable safer lots. If you think this was by accident—think again. This is not the first time “hot lots” were, in my opinion, purposefully manufactured and sent across the nation—usually vaccines designed for children. In one such scandal, “hot lots” of a vaccine ended up all in one state and the damage immediately became evident. What was the manufacture’s response? It wasn’t to remove the deadly batches of the vaccine. He ordered his company to scatter the hot lots across the nation so that authorities would not see the obvious deadly effect.

All lots of a vaccine are numbered—for example Modera labels them with such codes as 013M20A. It was noted that the batch numbers ended in either 20A or 21A. Batches ending in 20A were much more toxic than the ones ending in 21A. The batches ending in 20A had about 1700 adverse events, versus a few hundred to twenty or thirty events for the 21A batches. This example explains why some people had few or no adverse events after taking the vaccine while others are either killed or severely and permanently harmed. To see the researcher’s explanation, go to https://www.bitchute.com/video/6xIYPZBkydsu/ In my opinion these examples strongly suggest an intentional alteration of the production of the “vaccine” to include deadly batches.

I have met and worked with a number of people concerned with vaccine safety and I can tell you they are not the evil anti-vaxxers you are told they are. They are highly principled, moral, compassionate people, many of which are top researchers and people who have studied the issue extensively. Robert Kennedy, Jr, Barbara Lou Fisher, Dr. Meryl Nass, Professor Christopher Shaw, Megan Redshaw, Dr. Sherri Tenpenny, Dr. Joseph Mercola, Neil Z. Miller, Dr. Lucija Tomjinovic, Dr. Stephanie Seneff, Dr. Steve Kirsch and Dr. Peter McCullough just to name a few. These people have nothing to gain and a lot to lose. They are attacked viciously by the media, government agencies, and elite billionaires who think they should control the world and everyone in it.

WHY DID FAUCI WANT NO AUTOPSIES OF THOSE WHO DIED AFTER VACCINATION?

There are many things about this “pandemic” that are unprecedented in medical history. One of the most startling is that at the height of the pandemic so few autopsies, especially total autopsies, were being done. A mysterious virus was rapidly spreading around the world, a selected group of people with weakened immune systems were getting seriously ill and many were dying and the one way we could rapidly gain the most knowledge about this virus—an autopsy, was being discouraged.

Guerriero noted that by the end of April, 2020 approximately 150,000 people had died, yet there were only 16 autopsies performed and reported in the medical literature.[24] Among these, only seven were complete autopsies, the remaining 9 being partial or by needle biopsy or incisional biopsy. Only after 170,000 deaths by Covid-19 and four months into the pandemic were the first series of autopsies actually done, that is, more than ten. And only after 280,000 deaths and another month, were the first large series of autopsies performed, some 80 in number.[22] Sperhake, in a call for autopsies to be done without question, noted that the first full autopsy reported in the literature along with photomicrographs appeared in a medico-legal journal from China in February 2020.[41,68] Sperhake expressed confusion as to why there was a reluctance to perform autopsies during the crisis, but he knew it was not coming from the pathologists. The medical literature was littered with appeals by pathologist for more autopsies to be performed.[58] Sperhake further noted that the Robert Koch Institute (The German health monitoring system) at least initially advised against doing autopsies. He also knew that at the time 200 participating autopsy institutions in the United States had done at least 225 autopsies among 14 states.

Some have claimed that this dearth of autopsies was based on the government’s fear of infection among the pathologists, but a study of 225 autopsies on Covid-19 cases demonstrated only one case of infection among the pathologist and this was concluded to have been an infection contracted elsewhere.[19] Guerriero ends his article calling for more autopsies with this observation: “Shoulder to shoulder, clinical and forensic pathologists overcame the obstructions of autopsy studies in Covid-19 victims and hereby generated valuable knowledge on the pathophysiology of the interaction between the SARS-CoV-2 and the human body, thus contributing to our understanding of the disease.”[24]

Suspicion concerning the worldwide reluctance of nations to allow full post mortem studies of Covid-19 victims may be based on the idea that it was more than by chance. There are at least two possibilities that stand out. First, those leading the progression of this “non-pandemic” event into a perceived worldwide “deadly pandemic”, were hiding an important secret that autopsies could document. Namely, just how many of the deaths were actually caused by the virus? To implement draconian measures, such as mandated mask wearing, lockdowns, destruction of businesses, and eventually mandated forced vaccination, they needed very large numbers of covid-19 infected dead. Fear would be the driving force for all these destructive pandemic control programs.

Elder et al in his study classified the autopsy findings into four groups.[22]

  1. Certain Covid-19 death
  2. Probably Covid-19 death
  3. Possible Covid-19 death
  4. Not associated with Covid-19, despite the positive test.

What possibly concerned or even terrified the engineers of this pandemic was that autopsies just might, and did, show that a number of these so-called Covid-19 deaths in truth died of their comorbid diseases. In the vast majority of autopsy studies reported, pathologists noted multiple comorbid conditions, most of which at the extremes of life could alone be fatal. Previously it was known that common cold viruses had an 8% mortality in nursing homes.

In addition, valuable evidence could be obtained from the autopsies that would improve clinical treatments and could possibly demonstrate the deadly effect of the CDC mandated protocols all hospitals were required to follow, such as the use of respirators and the deadly, kidney-destroying drug remdesivir. The autopsies also demonstrated accumulating medical errors and poor-quality care, as the shielding of doctors in intensive care units from the eyes of family members inevitably leads to poorer quality care as reported by several nurses working in these areas.[5355]

As bad as all this was, the very same thing is being done in the case of Covid vaccine deaths—very few complete autopsies have been done to understand why these people died, that is, until recently. Two highly qualified researchers, Dr. Sucharit Bhakdi a microbiologist and highly qualified expert in infectious disease and Dr. Arne Burkhardt, a pathologist who is a widely published authority having been a professor of pathology at several prestigious institutions, recently performed autopsies on 15 people having died after vaccination. What they found explains why so many are dying and experiencing organ damage and deadly blood clots.[5]

They determined that 14 of the fifteen people died as a result of the vaccines and not of other causes. Dr. Burkhardt, the pathologist, observed widespread evidence of an immune attack on the autopsied individuals’ organs and tissues— especially their heart. This evidence included extensive invasion of small blood vessels with massive numbers of lymphocytes, which cause extensive cell destruction when unleashed. Other organs, such as the lungs and liver, were observed to have extensive damage as well. These findings indicate the vaccines were causing the body to attack itself with deadly consequences. One can easily see why Anthony Fauci, as well as public health officers and all who are heavily promoting these vaccines, publicly discouraged autopsies on the vaccinated who subsequently died. One can also see that in the case of vaccines, that were essentially untested prior to being approved for the general public, at least the regulatory agencies should have been required to carefully monitor and analyze all serious complications, and certainly deaths, linked to these vaccines. The best way to do that is with complete autopsies.

While we learned important information from these autopsies what is really needed are special studies of the tissues of those who have died after vaccination for the presence of spike protein infiltration throughout the organs and tissues. This would be critical information, as such infiltration would result in severe damage to all tissues and organs involved—especially the heart, the brain, and the immune system. Animal studies have demonstrated this. In these vaccinated individuals the source of these spike proteins would be the injected nanolipid carriers of the spike protein producing mRNA. It is obvious that the government health authorities and pharmaceutical manufacturers of these “vaccines” do not want these critical studies done as the public would be outraged and demand an end to the vaccination program and prosecution of the involved individuals who covered this up.

CONCLUSIONS

We are all living through one of the most drastic changes in our culture, economic system, as well as political system in our nation’s history as well as the rest of the world. We have been told that we will never return to “normal” and that a great reset has been designed to create a “new world order”. This has all been outlined by Klaus Schwab, head of the World Economic Forum, in his book on the “Great Reset”.[66] This book gives a great deal of insight as to the thinking of the utopians who are proud to claim this pandemic “crisis” as their way to usher in a new world. This new world order has been on the drawing boards of the elite manipulators for over a century.[73,74] In this paper I have concentrated on the devastating effects this has had on the medical care system in the United States, but also includes much of the Western world. In past papers I have discussed the slow erosion of traditional medical care in the United States and how this system has become increasingly bureaucratized and regimented.[7,8] This process was rapidly accelerating, but the appearance of this, in my opinion, manufactured “pandemic” has transformed our health care system over night.

As you have seen, an unprecedented series of events have taken place within this system. Hospital administrators, for example, assumed the position of medical dictators, ordering doctors to follow protocols derived not from those having extensive experience in treating this virus, but rather from a medical bureaucracy that has never treated a single COVID-19 patient. The mandated use of respirators on ICU Covid-19 patients, for example, was imposed in all medical systems and dissenting physicians were rapidly removed from their positions as caregivers, despite their demonstration of markedly improved treatment methods. Further, doctors were told to use the drug remdesivir despite its proven toxicity, lack of effectiveness and high complication rate. They were told to use drugs that impaired respiration and mask every patient, despite the patient’s impaired breathing. In each case, those who refused to abuse their patients were removed from the hospital and even faced a loss of license—or worse.

For the first time in modern medical history, early medical treatment of these infected patients was ignored nationwide. Studies have shown that early medical treatment was saving 80% of higher number of these infected people when initiated by independent doctors.[43,44] Early treatment could have saved over 640,000 lives over the course of this “pandemic”. Despite the demonstration of the power of these early treatments, the forces controlling medical care continued this destructive policy.

Families were not allowed to see their loved ones, forcing these very sick individuals in the hospitals to face their deaths alone. To add insult to injury, funerals were limited to a few grieving family members, who were not allowed to even sit together. All the while large stores, such as Walmart and Cosco were allowed to operate with minimal restrictions. Nursing home patients were also not allowed to have family visitations, again being forced to die a lonely death. All the while, in a number of states, the most transparent being in New York state, infected elderly were purposefully transferred from hospitals into nursing homes, resulting in a very high death rates of these nursing home residents. At the beginning of this “pandemic” over 50% of all death were occurring in nursing homes.

Throughout this “pandemic” we have been fed an unending series of lies, distortions and disinformation by the media, the public health officials, medical bureaucracies (CDC, FDA and WHO) and medical associations. Physicians, scientists, and experts in infectious treatments who formed associations designed to develop more effective and safer treatments, were regularly demonized, harassed, shamed, humiliated, and experience a loss of licensure, loss of hospital privileges and, in at least one case, ordered to have a psychiatric examination.[2,65,71]

Anthony Fauci was given essentially absolute control of all forms of medical care during this event, including insisting that drugs he profited from be used by all treating physicians. He ordered the use of masks, despite at first laughing at the use of masks to filter a virus. Governors, mayors, and many businesses followed his orders without question.

The draconian measures being used, masking, lockdowns, testing of the uninfected, use of the inaccurate PCR test, social distancing, and contact tracing had been shown previously to be of little or no use during previous pandemics, yet all attempts to reject these methods were to no avail. Some states ignored these draconian orders and had either the same or fewer cases, as well as deaths, as the states with the most strictly enforced measures. Again, no amount of evidence or obvious demonstration along these lines had any effect on ending these socially destructive measures. Even when entire countries, such as Sweden, which avoided all these measures, demonstrated equal rates of infections and hospitalization as nations with the strictest, very draconian measures, no policy change by the controlling institutions occurred. No amount of evidence changed anything.

Experts in the psychology of destructive events, such as economic collapses, major disasters and previous pandemics demonstrated that draconian measures come with an enormous cost in the form of “deaths of despair” and in a dramatic increase in serious psychological disorders. The effects of these pandemic measures on children’s neurodevelopment is catastrophic and to a large extent irreversible.

Over time tens of thousands could die as a result of this damage. Even when these predictions began to appear, the controllers of this “pandemic” continued full steam ahead. Drastic increases in suicides, a rise in obesity, a rise in drug and alcohol use, a worsening of many health measures and a terrifying rise in psychiatric disorders, especially depression and anxiety, were ignored by the officials controlling this event.

We eventually learned that many of the deaths were a result of medical neglect. Individuals with chronic medical conditions, diabetes, cancer, cardiovascular disease, and neurological diseases were no longer being followed properly in their clinics and doctor’s offices. Non-emergency surgeries were put on hold. Many of these patients chose to die at home rather than risk going to the hospitals and many considered hospitals “death houses”.

Records of deaths have shown that there was a rise in deaths among those aged 75 and older, mostly explained by Covid-19 infections, but for those between the ages of 65 to 74, deaths had been increasing well before the pandemic onset.[69] Between ages of 18 and aged 65 years, records demonstrate a shocking hike in non-Covid-19 deaths. Some of these deaths were explained by a dramatic increase in drug-related deaths, some 20,000 more than 2019. Alcohol related deaths also increased substantially, and homicides increased almost 30% in the 18 to 65-year group.

The head of the insurance company OneAmerica stated that their data indicated that the death rate for individuals aged 18 to 64 had increased 40% over the pre-pandemic period.[21] Scott Davidson, the company’s CEO, stated that this represented the highest death rate in the history of insurance records, which does extensive data collections on death rates each year. Davidson also noted that this high of a death rate increase has never been seen in the history of death data collection. Previous catastrophes of monumental extent increased death rates no more than 10 percent, 40% is unprecedented.

Dr. Lindsay Weaver, Indiana’s chief medical officer, stated that hospitalizations in Indiana are higher than at any point in the past five years. This is of critical importance since the vaccines were supposed to significantly reduce deaths, but the opposite has happened. Hospitals are being flooded with vaccine complications and people in critical condition from medical neglect caused by the lockdowns and other pandemic measures.[46,56]

A dramatic number of these people are now dying, with the spike occurring after the vaccines were introduced. The lies flowing from those who have appointed themselves as medical dictators are endless. First, we were told that the lockdown would last only two weeks, they lasted over a year. Then we were told that masks were ineffective and did not need to be worn. Quickly that was reversed. Then we were told the cloth mask was very effective, now it’s not and everyone should be wearing an N95 mask and before that that they should double mask. We were told there was a severe shortage of respirators, then we discover they are sitting unused in warehouses and in city dumps, still in their packing crates. We were informed that the hospitals were filled mostly with the unvaccinated and later found the exact opposite was true the world over. We were told that the vaccine was 95% effective, only to learn that in fact the vaccines cause a progressive erosion of innate immunity.

Upon release of the vaccines, women were told the vaccines were safe during all states of pregnancy, only to find out no studies had been done on safety during pregnancy during the “safety tests” prior to release of the vaccine. We were told that careful testing on volunteers before the EUA approval for public use demonstrated extreme safety of the vaccines, only to learn that these unfortunate subjects were not followed, medical complications caused by the vaccines were not paid for and the media covered this all up.[67] We also learned that the pharmaceutical makers of the vaccines were told by the FDA that further animal testing was unnecessary (the general public would be the Guinea pigs.) Incredibly, we were told that the Pfizer’s new mRNA vaccines had been approved by the FDA, which was a cleaver deception, in that another vaccine had approval (comirnaty) and not the one being used, the BioNTech vaccine. The approved comirnaty vaccine was not available in the United States. The national media told the public that the Pfizer vaccine had been approved and was no longer classed as experimental, a blatant lie. These deadly lies continue. It is time to stop this insanity and bring these people to justice.

Footnotes

How to cite this article: Blaylock RL. COVID UPDATE: What is the truth? Surg Neurol Int 2022;13:167.

Disclaimer

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Journal or its management.

Article information

Surg Neurol Int. 2022; 13: 167. 

Published online 2022 Apr 22. doi: 10.25259/SNI_150_2022

PMCID: PMC9062939

PMID: 35509555

Russell L. Blaylock

Retired Neurosurgeon, Theoretical Neuroscience Research, LLC, Ridgeland, Mississippi, United States.

Russell L. Blaylock: moc.liamg@7036yalB

*Corresponding author: Russell L. Blaylock, Theoretical Neuroscience Research, LLC, Ridgeland, Mississippi, United States. moc.liamg@7036yalB

Received 2022 Feb 6; Accepted 2022 Feb 11.

Copyright : © 2022 Surgical Neurology International

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Articles from Surgical Neurology International are provided here courtesy of Scientific Scholar

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62. Roche D.  Boston Herald. 2021. Sept 14, Members of Congress and their staff are exempt from Biden’s vaccine mandate, Newsweek 9/10/21 Boston Herald Editorial Staff. Editorial: Political elites exempt from vax mandates. [Google Scholar]

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64. Saul S. Ghostwriters used in Vioxx studies, article says. New York Times. April 15, 2008 https://www.fpparchive.org/media/documents/public_policy/Ghostwriters%20Used%20in%20Vioxx%20studies_Stephanie%20Saul_Apr%2015,%202008_The%20New%20Times.pdf[Last accessed on 2022 Feb 06]

65. Saxena V. Doctors loses medical license. Ordered to have Psych Eval for Ivermectin Scrits, Sharing Covid “misinformation” BRP News. Available from: https://bizpacreview.com/2022/01/16/doctor-loses-license-orderedto-have-psych-eval-for-prescribing-ivermectin-sharining-covid-falsehoods-1189313. [Last accessed on 2022 Feb 06]

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Prof Dolores Cahill – ‘Everyone Who Has Had an mRNA Injection Will Die Within 3-5 Years’

Professor Dolores Cahill’s research suggests that those vaccinated with an mRNA injection have between 3-5 years to live – even if they have had only one jab.

This is the most terrifying interview I’ve seen with Professor Dolores Cahill.

Everything that she has said over the last 2 years has been correct. I’ve heard this mentioned somewhere before, but to hear it from this Professor, sort of makes it hit home. I have 3 grown-up daughters who have had the jab, it’s frightening to know what I’ve just heard.

Click on the link below, there are other videos too.

https://adversereactionreport.com/scientific-evidence/prof-dolores-cahill-everyone-who-has-had-an-mrna-injection-will-die-within-3-5-years/

$9.8 Million Awarded Last Year by Fauci’s Agency to Test Monkeypox Treatment

Here’s something I have posted before. Google can not edit books.

Monkeypox can only be a serious problem for humans if it has been meddled with. For instance, GOF, ( gain of function )

The National Institute of Allergy and Infectious Diseases, directed by Dr. Anthony Fauci, last year paid $9.8 million to government researchers to test a monkeypox treatment. Some called the timing “curious” given the recent outbreak of the virus.

By 

Susan C. Olmstead

The National Institute of Allergy and Infectious Diseases (NIAID), directed by Dr. Anthony Fauci, last year paid $9.8 million to government researchers to test a monkeypox treatment, the National Pulse reported.

According to the National Institutes for Health (NIH), which oversees the NIAID, the research began Sept. 28, 2020 and will conclude Sept. 27, 2025. Its goal is to carry out a “randomized, placebo-controlled trial of the safety and efficacy of tecovirimat for the treatment of patients with monkeypox virus disease.” It is unclear if the grant provided for any payments in 2020.

The NIAID awarded the grant to the Frederick National Laboratory for Cancer Research, a federally funded research and development center in Frederick, Maryland, supported by the National Cancer Institute.

According to the grant abstract:

“The similarity between monkeypox and the variola [smallpox] virus, coupled with concerns about the potential of the variola virus as a potential bioterrorism agent, have placed monkeypox treatments at the forefront of public health and scientific research agendas in many countries.”

On May 25, SIGA Technologies Inc.announced that it received approval from the U.S. Food and Drug Administration (FDA) for an intravenous formulation of the antiviral tecovirimat (called TPOXX) for the treatment of smallpox.

Although smallpox was eradicated in 1980, the treatment was developed in the event smallpox were to be used as a bioweapon.

The U.S., Canada and Europe have approved an oral formulation of TPOXX for treating smallpox, and Europe also approved it for treating monkeypox and cowpox.

As of May 30, the NIH project had not generated any publicly available studies, papers or patents, according to The National Pulse.

The National Pulse called the timing of the grant “curious,” as it comes while pharmaceutical giants including Pfizer and Johson & Johnson are making record-level profits due to the COVID-19 pandemic.

Dr. Lori Dodd, a mathematical statistician in the biostatistics research branch of NIAID, is the project’s principal investigator.

On a recent segment of The Hill’s “Rising,” co-hosts Briahna Joy Gray and Kim Iversen reminded viewers that Dodd was “exposed for her involvement in the agency’s reported data altering of remdesivir trials to make [remdesivir] seem more effective against COVID.”

Iversen and Gray also found the timing of the funding suspicious.

“It could just be coincidental,” said Iversen, “ … but I will say that there is something very suspect about the fact that they started working on identifying treatments for monkeypox in September of 2020. This has been a virus that’s been around since 1970.”

However, Gray said, “in a world where everyone’s certainly concerned about viruses because of COVID-19, maybe the money simply started to flow in the fall of 2020.”

“What’s odd,” responded Iversen, “is that there’s now suddenly an outbreak [of monekypox] and that outbreak is making headlines and it’s spreading all around the world.”

Iversen implied the NIH may be hoping to develop a new treatment for monkeypox as public fear of the disease grows.

As The Defender has reported, others also questioned how unexpected the monkeypox outbreak was after learning about a March 2021 tabletop simulationof a hypothetical deadly outbreak of monkeypox predicted to occur in May 2022.

Some analysts suggested the outbreak may have resulted from gain-of-functionresearch or similar experiments involving the virus.

The National Pulse reported that a February 2022 peer-reviewed studyrevealed scientists performed a monkeypox-related gain-of-function research project at the Wuhan Institute of Virology in August 2021.

Below I have got hold of the actual tabletop

https://acrobat.adobe.com/link/review?uri=urn:aaid:scds:US:92deab25-7ef9-3a94-b965-7dbbd92dd6bc

Inquest due to Pfizer vaccine

An Inquest, Likely due to the family not expecting an ‘unexplained’ death and pushing for answers, is further proof of the dangers of the Pfizer Vaccine. Another healthy young woman, daughter, mother and wife has lost her life from being coerced by our lying governments, global ‘health agencies’ and big Pharma.

She leaves behind her year old son… How many more will we lose, how many children?

‘A post-mortem examination on the body of Dawn Wooldridge had previously proved inconclusive but an inquest heard on Thursday that the unexpected death, which happened 11 days after Dawn’s first Covid jab, was likely caused as a result of the vaccination.

The 36-year-old was found dead in her home by her brother in June last year, after she failed to collect her five-year-old son from school that day.

In a statement to the Berkshire coroner by Dawn’s husband, Ashley, he said: “We met on holiday in Turkey and we have been married for seven years this year.’

t.me/FionaRoseDiamond

Davos Man, his World Economic Forum, and his Servants

The purpose of this essay and the accompanying spreadsheet is to provide you with information and transparency about who these people are, where they come from, what their ethics and policy positions are, where they work, what sectors they work in, and when they were trained to do the bidding of the World Economic Forum (“WEF”).

These people have been trained to believe in and support a globalist form of unelected government, in which business is at the centre of the management and decision-making process.  They are fundamentally anti-democratic, and their views are both fundamentally corporatist and globalist, which is another way of saying that they are for totalitarian fascism – the fusion of the interests of business with the power of the state – on a global scale.

The Malone Institute, in collaboration with the Pharos Foundation and Pharos Media Productions in Sweden, has invested months of time and hundreds of labour hours to mine existing and historic publicly available data sources to develop a detailed summary of graduates from two WEF training programs; Global Leaders of Tomorrow (a one-year program that ran from 1993 to 2003) and Young Global Leaders (a five-year program started 2004/2005 and still running).

Who are the globalist members of the trade organisation known as The World Economic Forum (“WEF”) and their servants, why should you care, and what can you do about it? 

First, “who are they?” 

The current 100 WEF full members (“Strategic Partners”) are drawn from the largest corporations in the world, together with their owners and managers (referred to as “Davos Man”).  The list of corporations, owners and managers who control the WEF is not disclosed and membership can only be inferred indirectly.  However, the WEF members do not act alone, but have developed various groups of globally distributed trainees who generally act in accordance with the detailed policies and positions developed and distributed by WEF leadership.  These training programs have been operating for over three decades, resulting in placement, distribution and rapid advancement of many thousands of WEF-trained operatives throughout the world.  WEF chairman Klaus Schwab has famously claimed that these operatives have been strategically inserted into key positions in various governments, as well as influential spots in key industries such as media, finance, and technology. 

Davos Man” is a term coined by former Harvard University Director of the Centre for International Affairs Professor Dr. Samuel Huntington (1927-2008) to define an emerging group of economic elites who are members of a social caste which has “little need for national loyalty, view national boundaries as obstacles that are thankfully vanishing, and see national governments as residues from the past whose only useful function is to facilitate the elite’s global operations.”  The title of his prescient 2004 article published in The National Interest is telling: “Dead Souls: The Denationalisation of the American Elite”.

In a 2005 article published in The Guardian titled “Davos man’s death wish”, Timothy Garton Ash described Davos Man and the World Economic Forum:

Davos Man is mainly white, middle-aged and European or Anglo-Saxon. Of course, some of the participants at this year’s five-day meeting of the World Economic Forum in the Swiss mountain resort were Indian, Chinese, African or/and women. But they continue to be a minority. The dominant culture of Davos remains that of white western man

Davos man has a troublesome pre-history of combining brilliance and stupidity, of being blinded by national and ideological prejudice to his own long-term interest and destroying with one hand what he has built with the other.”

Wikipedia defines “megalomania” as “an obsession with power and wealth, and a passion for grand schemes.”  It also relates this term to the following psychological terms: Narcissistic personality disorderGrandiose delusions, and Omnipotence (psychoanalysis), a stage of child development. Davos Man fits the definition of megalomania and has acquired what he believes are the financial and political resources to try to force his obsession and grand schemes on the world, and to force you, your family, and the world to comply with his vision.

Regarding the WEF, Andrew Marshall developed a brief introductory summary which I strongly recommend reading, published in a 2015 article entitled “World Economic Forum: a history and analysis”. The membership of the WEF is divided into three categories: Regional Partners, Industry Partner Groups, and the most esteemed, the Strategic Partners. Membership fees from corporations and industry groups finance the Forum and provide the member company with extra access and to set the agenda. A full list of current Strategic Partners can be found HERE.

“Why should you care?” 

The WEF is the organisation which has masterminded the globally harmonised planning, development and implementation of the lockdowns, mandates, authoritarian vaccine campaigns, suppression of early treatment options, global targeting of dissenting physicians, censorship, propaganda, information and thought control programs which we have all experienced since late 2019.  This is the organisational structure used by the ones who have sought to control and manage the world to advance the economic and political interests of their members through the ongoing “Great Reset” (as named and described by their chairman Klaus Schwab) by exploiting and exacerbating the social and economic disruption which they have artificially and intentionally crafted since SARS-CoV-19 began spreading across the world. 

The musings and plans of this trade organisation read and sound like the implausible sinister plot of an international spy novel concocted by a second-rate version of Ian Fleming, John Le Carre, or Robert Ludlum.  Unfortunately, they are backed by the financial resources of many of the wealthiest people in the world.  For examples of the muddled thinking and pseudo-science which these self-appointed masters of the universe proudly publish, I recommend that you do your best to read COVID-19: The Great ResetThe Great Narrative for a better future (both by Klaus Schwab and Thierry Malleret), and How to Prevent the Next Pandemic (by Bill Gates).  A detailed interactive summary of their policy positions and the interrelationships of those policies (“transformation map”) can be found HERE and for COVID-19, HERE.

“What can you do about it?” 

After all you have seen and experienced since September 2019, please look in the mirror and ask yourself these two questions:

Are these people I can trust with my future and that of my children?

“Do they represent my interests, values, and what I believe in?”

If you decide that you cannot trust them, or that they do not share your interests and values, then it is high time to act to prevent them from taking control of all aspects of your life.  Otherwise, the WEF seeks to take away everything you own, and to completely control all aspects of your life.  One of the key predictions of their “Global Future Councils” is that by 2030, you (or your children) will own nothing, and will be happy.  Here is a LINK to other aspects of their vision of tomorrow.

If not us, who?  If not now, when

Susan George, “Whose Crisis, Whose Future?”  (Polity Press and John Wiley & Sons, 2010)

Whatever your answer, you deserve to know who these people are that wish to control the world, your daily life, what information you can access, what you are allowed to think, and what you are allowed to own.  You deserve to know who they represent, and what are their names.  The purpose of this essay and the accompanying spreadsheet is to provide you with information and transparency about who these people are, where they come from, what their ethics and policy positions are, where they work, what sectors they work in, and when they were trained to do the bidding of the WEF (there are often close bonds between members of the same class year). 

These people have been trained to believe in and support a globalist form of unelected government, in which business is at the centre of the management and decision-making process.  They have been trained to advance the interests of a global transnational government which represents a public-private partnership in which the business interests of the WEF members take precedence over the constitution of the United States.  The WEF believes that the concept of independent nation-states is obsolete and must be replaced with a global government which controls all.  They are fundamentally anti-democratic, and their views are both fundamentally corporatist and globalist, which is another way of saying that they are for totalitarian fascism – the fusion of the interests of business with the power of the state – on a global scale. These people do not represent the interests of the nation-state in which they reside, work, and may hold political office, but rather their allegiance appears to be to the WEF vision of a dominant world government which has dominion over nations and their constitutions.  In my opinion, in the case of those trainees and WEF members who are in politics, and particularly those who have been used to “penetrate the global cabinets of countries”, these persons should be forced to register as foreign agents within their host countries.

Davos Man’s Servants are Foreign Agents. The full title of the US Foreign Principal Registration Act of 1938 (FARA) is “An Act to require the registration of certain persons employed by agencies to disseminate propaganda in the United States and for other purposes.”  Citing Wikipedia,

“The Foreign Agents Registration Act (FARA) (2 U.S.C. § 611 et seq.) is a United States law requiring persons engaged in domestic political or advocacy work on behalf of foreign interests to register with the Department of Justice and disclose their relationship, activities, and related financial compensation. Its purpose is to allow the government and general public to be informed of the identities of individuals representing the interests of foreign governments or entities. The law is administered and enforced (or not…) by the FARA Unit of the Counterintelligence and Export Control Section (CES) in the National Security Division (NSD).”

The List of WEF Trainees

The Malone Institute (primarily Dr. Jill Glasspool-Malone and Anita Hasbury-Snogles), in collaboration with the Pharos Foundation and Pharos Media Productions in Sweden, has invested months of time and hundreds of labour hours to mine existing and historic publicly available data sources to develop a detailed summary of graduates from two WEF training programs; the World Economic Forum’s Global Leaders of Tomorrow (a one-year program that ran from 1993 to 2003) and Young Global Leaders (a five-year program started 2004/2005 and still running).  Pharos foundations’ summary can be found here. These people have been intentionally and internationally deployed as foreign agents representing the interests of the WEF members to “penetrate the global cabinets of countries” as well as a wide range of key business sectors including banking/finance, other business sectors (including health and biotechnology), academia and health, media, technology, logistics, arts and culture, sports, politics and government, think tanks, telecommunications, real estate, financial investment/holding companies, a variety of non-governmental organisations, energy, aerospace and military, food and agriculture. 

This list can be found and downloaded at the following link:

THIS IS THE LIST OF WEF TRAINEES

The list contains a summary of the graduates of the World Economic Forum’s Global Leaders of Tomorrow (a one-year program that ran from 1993 to 2003) as well as the Young Global Leaders (a five-year program started 2004/2005 and still running).

To create this list, the Malone Institute and the Pharos Foundation have used World Economic Forum search engines and cross-checked published lists, Wayback Machine archives, Wikispooks, and other complementary sources. It may not be 100% accurate, but we have done our best to make it as correct and updated as possible.  Some people have been removed from the WEF website, and some were never listed but have been identified by Klaus Schwab himself as members of his young global agents of change. We have done extensive manual research in order to identify and verify those for whom very little information has been provided. When missing, there has been an attempt to find and add relevant countries, positions etc.  When identified, links have been provided to existing biographies, primarily those included in World Economic Forum webpages, or else Wikipedia, LinkedIn, company pages, or articles. In some cases (when available) we have also provided links to organisations they have worked at. When possible, positions and organisations in many cases have been updated to the most recent identifiable.

The Sector designations chosen by WEF have changed over the years, so the spreadsheet uses the most descriptive term for their updated sector and position, but in some cases we have added our own – especially in the Business sector where we have added Sub-sectors for more detailed information. The Region designations used by WEF have also changed over the years, so we have used simpler geographical regions. We have added extra columns in the spreadsheet for Sex, Political position, Health connection, and finally Notes for additional or relevant information.

This list is open to corrections and additions, should anyone spot an error or have more information.  Please write to us at info@MaloneInstitute.org  if you have additional information, details, or corrections.

Once again, here is the LANDING PAGE WHERE YOU CAN DOWNLOAD THE DEFINITIVE LIST OF WEF YLT and GLT GRADUATES

Source Information

So that you can cross-check for yourself, below are provided hyperlinked sources for this summary, which includes only the listed groups (GLT = Global Leaders of Tomorrow, YGL = Young Global Leaders). There are additional WEF trainee groups including “Young Scientists”, and these will be the focus of future similar summary spreadsheets. The lists below do not contain the full documentation of the members found on our master list above.

GLT class of 1993

GLT class of 1994

GLT class of 1995

GLT class of 1996

GLT class of 1997

GLT class of 1998

GLT class of 1999

GLT class of 2000

GLT class of 2001

GLT class of 2002

GLT class of 2003

According to economist Richard Werner, who was selected for the GLT program in 2003, the Global Leaders of Tomorrow program (GLT) was closed down and rebooted as a more controllable group called the “Young Global Leaders” (YGL) because too many people were asking difficult questions in the forum (see “Last American Vagabond” podcast titled “COVID Measures And The Central Controls Over The Economy” here).  Many of the more recently graduate classes are explicitly identified as revolutionaries who are “Driving the Fourth Industrial Revolution” on behalf of the WEF.

YGL class of 2005

YGL class of 2006

YGL class of 2007 (select year 2007 on the tab at right)

YGL class of 2008 (select year 2008 on the tab at right)

YGL class of 2009

YGL class of 2010

YGL class of 2011

YGL class of 2012

YGL class of 2013

YGL class of 2014

YGL class of 2015

YGL class of 2016

YGL class of 2017

YGL class of 2018

YGL class of 2019

YGL class of 2020

YGL class of 2021

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

From the NIH website

There are hundreds of references at the end of this paper and it’s in plain sight on the NIH website 4/5/2022

Mingyang Tang, Xiaodong Hu, […], and Qiang Fang

Graphical abstract

Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.

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Abbreviations: ASC, Apoptosis-associated speck-like protein containing a CARD; ALCAR, acetyl-L-carnitine; CSCs, Cancer stem cells; DAMP, Damage-associated molecular pattern; EGFR, Epidermal growth factor receptor; EBV, Epstein-Barr virus; EMT, Epithelial mesenchymal-transition; GABA, Gamma-aminobutyric acid; GSDMD, Gasdermin D; HBV, Hepatitis B virus; HCV, Hepatitis C virus; HER2, Human epidermal growth factor receptor 2; HMGB1, High mobility group box-1 protein; HSP27, Heat shock protein 27; LD50, median lethal dose; LDH, Lactate dehydrogenase; IVM, Ivermectin; MDR, Multidrug resistance; NAC, N-acetyl-L-cysteine; OCT-4, Octamer-binding protein 4; PAK1, P-21-activated kinases 1; PAMP, Pathogen-associated molecular pattern; PARP, poly (ADP- ribose) polymerase; P-gp, P-glycoprotein; PRR, pattern recognition receptor; ROS, Reactive oxygen species; STAT3, Signal transducer and activator of transcription 3; SID, SIN3-interaction domain; siRNA, small interfering RNA; SOX-2, SRY-box 2; TNBC, Triple-negative breast cancer; YAP1, Yes-associated protein 1

Chemical compounds reviewed in this article: ivermectin(PubChem CID:6321424), avermectin(PubChem CID:6434889), selamectin(PubChem CID:9578507), doramectin(PubChem CID:9832750), moxidectin(PubChem CID:9832912)

Keywords: ivermectin, cancer, drug repositioning

Abstract

Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies. Satoshi ōmura and William C. Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasitic diseases. Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways. This suggests that ivermectin may be an anticancer drug with great potential. Here, we reviewed the related mechanisms by which ivermectin inhibited the development of different cancers and promoted programmed cell death and discussed the prospects for the clinical application of ivermectin as an anticancer drug for neoplasm therapy.

1. Introduction

Ivermectin(IVM) is a macrolide antiparasitic drug with a 16-membered ring derived from avermectin that is composed of 80% 22,23-dihydroavermectin-B1a and 20% 22,23-dihydroavermectin-B1b [1]. In addition to IVM, the current avermectin family members include selamectin, doramectin and moxidectin [[2][3][4][5]] (Fig. 1 ). IVM is currently the most successful avermectin family drug and was approved by the FDA for use in humans in 1978 [6]. It has a good effect on the treatment of parasitic diseases such as river blindness, elephantiasis, and scabies. The discoverers of IVM, Japanese scientist Satoshi ōmura and Irish scientist William C. Campbell, won the Nobel Prize in Physiology or Medicine in 2015 [7,8]. IVM activates glutamate-gated chloride channels in the parasite, causing a large amount of chloride ion influx and neuronal hyperpolarization, thereby leading to the release of gamma-aminobutyric acid (GABA) to destroy nerves, and the nerve transmission of muscle cells induces the paralysis of somatic muscles to kill parasites [9,10]. IVM has also shown beneficial effects against other parasitic diseases, such as malaria [11,12], trypanosomiasis [13], schistosomiasis [14], trichinosis [15] and leishmaniasis [16].

Fig. 1

Fig. 1

The chemical structures of ivermectin and other avermectin family compounds in this review.

IVM not only has strong effects on parasites but also has potential antiviral effects. IVM can inhibit the replication of flavivirus by targeting the NS3 helicase [17]; it also blocks the nuclear transport of viral proteins by acting on α/β-mediated nuclear transport and exerts antiviral activity against the HIV-1 and dengue viruses [18]. Recent studies have also pointed out that it has a promising inhibitory effect on the SARS-CoV-2 virus, which has caused a global outbreak in 2020 [19]. In addition, IVM shows potential for clinical application in asthma [20] and neurological diseases [21]. Recently scientists have discovered that IVM has a strong anticancer effect.

Since the first report that IVM could reverse tumor multidrug resistance (MDR) in 1996 [22], a few relevant studies have emphasized the potential use of IVM as a new cancer

treatment [[23][24][25][26][27]]. Despite the large number of related studies, there are still some key issues that have not been resolved. First of all, the specific mechanism of IVM-mediated cytotoxicity in tumor cells is unclear; it may be related to the effect of IVM on various signaling pathways, but it is not very clear overall. Second, IVM seems to induce mixed cell death in tumor cells, which is also a controversial issue. Therefore, this review summarized the latest findings on the anticancer effect of IVM and discussed the mechanism of the inhibition of tumor proliferation and the way that IVM induces tumor programmed cell death to provide a theoretical basis for the use of IVM as a potential anticancer drug. As the cost of the research and development of new anticancer drugs continues to increase, drug repositioning has become increasingly important. Drug repositioning refers to the development of new drug indications that have been approved for clinical use [28]. For some older drugs that are widely used for their original indications and have clinical data and safety information, drug repositioning allows them to be developed via a cheaper and faster cycle and to be used more effectively in clinical use clinically [29]. Here, we systematically summarized the anticancer effect and mechanism of IVM, which is of great significance for the repositioning of IVM for cancer treatment.

2. The role of IVM in different cancers

2.1. Breast cancer

Breast cancer is a malignant tumor produced by gene mutation in breast epithelial cells caused by multiple carcinogens. The incidence of breast cancer has increased each year, and it has become one of the female malignant tumors with the highest incidence in globally. On average, a new case is diagnosed every 18 seconds worldwide [30,31]. After treatment with IVM, the proliferation of multiple breast cancer cell lines including MCF-7, MDA-MB-231 and MCF-10 was significantly reduced. The mechanism involved the inhibition by IVM of the Akt/mTOR pathway to induce autophagy and p-21-activated kinase 1(PAK1)was the target of IVM for breast cancer [32]. Furthermore, Diao’s study showed that IVM could inhibit the proliferation of the canine breast tumor cell lines CMT7364 and CIPp by blocking the cell cycle without increasing apoptosis, and the mechanism of IVM may be related to the inhibition of the Wnt pathway [33].

Triple-negative breast cancer (TNBC) refers to cancer that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2(HER2) and is the most aggressive subtype of breast cancer with the worst prognosis. In addition, there is also no clinically applicable therapeutic drug currently [34,35]. A drug screening study of TNBC showed that IVM could be used as a SIN3-interaction domain (SID) mimic to selectively block the interaction between SID and paired a-helix2. In addition, IVM regulated the expression of the epithelial mesenchymal-transition (EMT) related gene E-cadherin to restore the sensitivity of TNBC cells to tamoxifen, which implies the possibility that IVM functions as an epigenetic regulator in the treatment of cancer[36].

Recent studies have also found that IVM could promote the death of tumor cells by regulating the tumor microenvironment in breast cancer. Under the stimulation of a tumor microenvironment with a high level of adenosine triphosphate (ATP) outside tumor cells, IVM could enhance the P2 × 4/ P2 × 7/Pannexin-1 mediated release of high mobility group box-1 protein (HMGB1) [37]. However, the release of a large amount of HMGB1 into the extracellular environment will promote immune cell-mediated immunogenic death and inflammatory reactions, which will have an inhibitory effect on the growth of tumor cells. Therefore, we believe that the anticancer effect of IVM is not limited to cytotoxicity, but also involves the regulation of the tumor microenvironment. IVM regulates the tumor microenvironment and mediates immunogenic cell death, which may be a new direction for research exploring anticancer mechanisms in the future.

2.2. Digestive system cancer

Gastric cancer is one of the most common malignant tumors worldwide. In the past year, more than one million patients with gastric cancer have been diagnosed worldwide [38]. Nambara’s study showed that IVM could significantly inhibit the proliferation of gastric cancer cells in vivo and in vitro and that the inhibitory effect of IVM depended on the expression of Yes-associated protein 1(YAP1)[39]. The gastric cancer cell lines MKN1 and SH-10-TC have higher YAP1 expression than MKN7 and MKN28 cells, so MKN1 and SH-10-TC cells are sensitive to IVM, while MKN7 and MKN28 are not sensitive to IVM.YAP1 plays an oncogenic role in tumorigenesis, indicating the possibility of the use of IVM as a YAP1 inhibitor for cancer treatment [40].

In a study that screened Wnt pathway inhibitors, IVM inhibited the proliferation of multiple cancers, including the colorectal cancer cell lines CC14, CC36, DLD1, and Ls174 T, and promoted apoptosis by blocking the Wnt pathway [41]. After intervention with IVM, the expression of caspase-3 in DLD1 and Ls174 T cells increased, indicating that IVM has an apoptosis-inducing effect and inhibits the expression of the downstream genes AXIN2, LGR5, and ASCL2 in the Wnt/β-catenin pathway. However, the exact molecular target of IVM that affects the Wnt/β-catenin pathway remains to be explored.

Hepatocellular carcinoma is the fourth leading cause of cancer death worldwide. Approximately 80% of cases of liver cancer are caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) infection [42]. IVM could inhibit the development of hepatocellular carcinoma by blocking YAP1 activity in spontaneous liver cancer Mob1b-/-mice [43].Cholangiocarcinoma is a malignant tumor that originates in the bile duct inside and outside the liver. Intuyod’s experiment found that IVM inhibited the proliferation of KKU214 cholangiocarcinoma cells in a dose- and time-dependent manner [44]. IVM halted the cell cycle in S phase and promoted apoptosis. Surprisingly, gemcitabine-resistant KKU214 cells showed high sensitivity to IVM, which suggested that IVM shows potential for the treatment of tumors that are resistant to conventional chemotherapy drugs.

2.3. Urinary system cancer

Renal cell carcinoma is a fatal malignant tumor of the urinary system derived from renal tubular epithelial cells. Its morbidity has increased by an average of 2% annually worldwide and the clinical treatment effect is not satisfactory [[45][46][47]]. Experiments confirmed that IVM could significantly inhibit the proliferation of five renal cell carcinoma cell lines without affecting the proliferation of normal kidney cells, and its mechanism may be related to the induction of mitochondrial dysfunction [48]. IVM could significantly reduce the mitochondrial membrane potential and inhibit mitochondrial respiration and ATP production. The presence of the mitochondrial fuel acetyl-L-carnitine (ALCAR), and the antioxidant N-acetyl-L-cysteine (NAC), could reverse IVM-induced inhibition. In animal experiments, the immunohistochemical results for IVM-treated tumor tissues showed that the expression of the mitochondrial stress marker HEL was significantly increased, and the results were consistent with those of the cell experiments.

Prostate cancer is a malignant tumor derived from prostate epithelial cells, and its morbidity is second only to that of lung cancer among men in Western countries [49]. In Nappi’s experiment, it was found that IVM could enhance the drug activity of the anti-androgen drug enzalutamide in the prostate cancer cell line LNCaP and reverse the resistance of the prostate cancer cell line PC3 to docetaxel [50]. Interestingly, IVM also restored the sensitivity of the triple-negative breast cancer to the anti-estrogen drug tamoxifen [36], which also implies the potential for IVM to be used in endocrine therapy. Moreover, IVM was also found to have a good inhibitory effect on the prostate cancer cell line DU145 [51].

2.4. Hematological cancer

Leukemia is a type of malignant clonal disease caused by abnormal hematopoietic stem cells [52]. In an experiment designed to screen potential drugs for the treatment of leukemia, IVM preferentially killed leukemia cells at low concentrations without affecting normal hematopoietic cells [51]. The mechanism was related to the increase in the influx of chloride ions into the cell by IVM, resulting in hyperpolarization of the plasma membrane and induction of reactive oxygen species (ROS) production. It was also proven that IVM has a synergistic effect with cytarabine and daunorubicin on the treatment of leukemia. Wang’s experiment found that IVM could selectively induce mitochondrial dysfunction and oxidative stress, causing chronic myeloid leukemia K562 cells to undergo increased caspase-dependent apoptosis compared with normal bone marrow cells [53]. It was also confirmed that IVM inhibited tumor growth in a dose-dependent manner, and dasatinib had improved efficacy.

2.5. Reproductive system cancer

Cervical cancer is one of the most common gynecological malignancies, resulting in approximately 530,000 new cases and 270,000 deaths worldwide each year. The majority of cervical cancers are caused by human papillomavirus (HPV) infection [54,55]. IVM has been proven to significantly inhibit the proliferation and migration of HeLa cells and promote apoptosis [56]. After intervention with IVM, the cell cycle of HeLa cells was blocked at the G1/S phase, and the cells showed typical morphological changes related to apoptosis.

Ovarian cancer is a malignant cancer that lacks early clinical symptoms and has a poor therapeutic response. The 5-year survival rate after diagnosis is approximately 47% [27,57]. In a study by Hashimoto, it found that IVM inhibited the proliferation of various ovarian cancer cell lines, and the mechanism was related to the inhibition of PAK1 kinase [58]. In research to screen potential targets for the treatment of ovarian cancer through the use of an shRNA library and a CRISPR/Cas9 library, the oncogene KPNB1 was detected. IVM could block the cell cycle and induce cell apoptosis through a KPNB1-dependent mechanism in ovarian cancer [59]. Interestingly, IVM and paclitaxel have a synergistic effect on ovarian cancer, and combined treatment in in vivo experiments almost completely inhibited tumor growth. Furthermore, according to a report by Zhang, IVM can enhance the efficacy of cisplatin to improve the treatment of epithelial ovarian cancer, and the mechanism is related to the inhibition of the Akt/mTOR pathway [60].

2.6. Brain glioma

Glioma is the most common cerebral tumor and approximately 100,000 people worldwide are diagnosed with glioma every year. Glioblastoma is the deadliest glioma, with a median survival time of only 14-17 months [61,62]. Experiments showed that IVM inhibited the proliferation of human glioblastoma U87 and T98 G cells in a dose-dependent manner and induced apoptosis in a caspase-dependent manner [63]. This was related to the induction of mitochondrial dysfunction and oxidative stress. Moreover, IVM could induce apoptosis of human brain microvascular endothelial cells and significantly inhibit angiogenesis. These results showed that IVM had the potential to resist tumor angiogenesis and tumor metastasis. In another study, IVM inhibited the proliferation of U251 and C6 glioma cells by inhibiting the Akt/mTOR pathway [64].

In gliomas, miR-21 can regulate the Ras/MAPK signaling pathway and enhance its effects on proliferation and invasion [65]. The DDX23 helicase activity affects the expression of miR-12 [66]. IVM could inhibit the DDX23/miR-12 signaling pathway by affecting the activity of DDX23 helicase, thereby inhibiting malignant biological behaviors. This indicated that IVM may be a potential RNA helicase inhibitor and a new agent for of tumor treatment. However, here, we must emphasize that because IVM cannot effectively pass the blood-brain barrier [67], the prospect of the use of IVM in the treatment of gliomas is not optimistic.

2.7. Respiratory system cancer

Nasopharyngeal carcinoma is a malignant tumor derived from epithelial cells of the nasopharyngeal mucosa. The incidence is obviously regional and familial, and Epstein-Barr virus (EBV) infection is closely related [68]. In a study that screened drugs for the treatment of nasopharyngeal cancer, IVM significantly inhibited the development of nasopharyngeal carcinoma in nude mice at doses that were not toxic to normal thymocytes [69]. In addition, IVM also had a cytotoxic effect on a variety of nasopharyngeal cancer cells in vitro, and the mechanism is related to the reduction of PAK1 kinase activity to inhibit the MAPK pathway.

Lung cancer has the highest morbidity and mortality among cancers [70]. Nishio found that IVM could significantly inhibit the proliferation of H1299 lung cancer cells by inhibiting YAP1 activity [43]. Nappi’s experiment also proved that IVM combined with erlotinib to achieved a synergistic killing effect by regulating EGFR activity and in HCC827 lung cancer cells [50]. In addition, IVM could reduce the metastasis of lung cancer cells by inhibiting EMT.

2.8. Melanoma

Melanoma is the most common malignant skin tumor with a high mortality rate. Drugs targeting BRAF mutations such as vemurafenib, dabrafenib and PD-1 monoclonal antibodies, including pembrolizumab and nivolumab have greatly improved the prognosis of melanoma [71,72]. Gallardo treated melanoma cells with IVM and found that it could effectively inhibit melanoma activity [73]. Interestingly, IVM could also show activity against BRAF wild-type melanoma cells, and its combination with dapafinib could significantly increase antitumor activity. Additionally, it has been confirmed that PAK1 is the key target of IVM that mediates its anti-melanoma activity, and IVM can also significantly reduce the lung metastasis of melanoma in animal experiments. Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells [74]. However, NAC reversed the effect of IVM, which indicated that IVM increased TFE3-dependent autophagy through the ROS signaling pathway.

3. IVM-induced programmed cell death in tumor cells and related mechanisms

3.1. Apoptosis

IVM induces different programmed cell death patterns in different tumor cells (Table 1). As shown in Table 1, the main form of IVM induced programmed cell death is apoptosis. Apoptosis is a programmed cell death that is regulated by genes to maintain cell stability. It can be triggered by two activation pathways: the endogenous endoplasmic reticulum stress/mitochondrial pathway and the exogenous death receptor pathway [75,76]. The decrease in the mitochondrial membrane potential and the cytochrome c is released from mitochondria into the cytoplasm was detected after the intervention of IVM in Hela cells [56].Therefore, we infer that IVM induces apoptosis mainly through the mitochondrial pathway. In addition, morphological changed caused by apoptosis, including chromatin condensation, nuclear fragmentation, DNA fragmentation and apoptotic body formation were observed. Finally, IVM changed the balance between apoptosis-related proteins by upregulating the protein Bax and downregulating anti-apoptotic protein Bcl-2, thereby activating caspase-9/-3 to induce apoptosis [48,53,63] (Fig. 2 ).

Table 1

Table 1

Summary of IVM promotes programmed cell death.

Fig. 2

Fig. 2

Mechanisms of IVM-induced mitochondria-mediated apoptosis.

3.2. Autophagy

Autophagy is a lysosomal-dependent form of programmed cell death. It utilizes lysosomes to eliminate superfluous or damaged organelles in the cytoplasm to maintain homeostasis. It is characterized by double-layered or multilayered vacuolar structures containing cytoplasmic components, which are known as autophagosomes [77]. In recent years, many studies have shown that autophagy is a double-edged sword in tumor development. On the one hand, autophagy can help tumors adapt to the nutritional deficiency of the tumor microenvironment, and to a certain extent, protect tumor cells from chemotherapy- or radiotherapy- induced injury. On the other hand, some autophagy activators can increase the sensitivity of tumors to radiotherapy and chemotherapy by inducing autophagy, and excessive activation of autophagy can also lead to tumor cell death [[78][79][80][81]]. Overall, the specific environment of tumor cells will determine whether autophagy enhances or inhibits tumor development and improving autophagy activity has also become a new approach in cancer therapy. Programmed cell death mediated by autophagy after IVM intervention and the enhancement of the anticancer efficacy of IVM by regulating autophagy are interesting topics. Intervention with IVM in the breast cancer cell lines MCF-7 and MDA-MB-231 significantly increased intracellular autophagic flux and the expression of key autophagy proteins such as LC3, Bclin1, Atg5, and the formation of autophagosomes can be observed [32]. However, after using the autophagy inhibitors chloroquine and wortmannin or knocking down Bclin1 and Atg5 by siRNA to inhibit autophagy, the anticancer activity of IVM significantly decreased. This proves that IVM mainly exerts an antitumor effect through the autophagy pathway. In addition, researchers also used the Akt activator CA-Akt to prove that IVM mainly induces autophagy by inhibiting the phosphorylation of Akt and mTOR (Fig. 3). The phenomenon of IVM-induced autophagy has also been reported in glioma and melanoma [ 64,74]. All of the above findings indicate the potential of IVM as an autophagy activator to induce autophagy-dependent death in tumor cells.

Fig. 3

Fig. 3

Mechanisms of IVM-induced PAK1/Akt/mTOR-mediated autophagy.

3.3. Cross talk between IVM-induced apoptosis and autophagy

The relationship between apoptosis and autophagy is very complicated, and the cross talk between the two plays a vital role in the development of cancer [82]. Obviously, the existing results suggest that IVM-induced apoptosis and autophagy also exhibit cross talk. For example, it was found in SK-MEL-28 melanoma cells that IVM can promote apoptosis as well as autophagy [74]. After using the autophagy inhibitor bafilomycin A1 or siRNA to downregulate Beclin1, IVM-induced apoptosis was significantly enhanced, which suggested that enhanced autophagy will reduce IVM-induced apoptosis and that IVM-induced autophagy can protect tumor cells from apoptosis. However, in breast cancer cell experiments, it was also found that IVM could induce autophagy, and enhanced autophagy could increase the anticancer activity of IVM [37]. The latest research shows that in normal circumstances autophagy will prevent the induction of apoptosis and apoptosis-related caspase enzyme activation will inhibit autophagy. However, in special circumstances, autophagy may also help to induce apoptosis or necrosis [83]. In short, the relationship between IVM-induced apoptosis and autophagy involves a complex regulatory mechanism, and the specific molecular mechanism needs further study. We believe that deeper exploration of the mechanism can further guide the use of IVM in the treatment of cancer.

3.4. Pyroptosis

Pyroptosis is a type of inflammatory cell death induced by inflammasomes. The inflammasome is a multimolecular complex containing pattern recognition receptor (PRR), apoptosis-associated speck-like protein containing a CARD (ASC), and pro-caspase-1. PRR can identify pathogen-associated molecular patterns (PAMPs) that are structurally stable and evolutionarily conserved on the surface of pathogenic microorganisms and damage-associated molecular patterns (DAMPs) produced by damaged cells [84,85]. Inflammasomes initiate the conversion of pro-caspase-1 via self-shearing into activated caspase-1. Activated caspase-1 can cause pro-IL-1β and pro-IL-18 to mature and to be secreted. Gasdermin D(GSDMD)is a substrate for activated caspase-1 and is considered to be a key protein in the execution of pyroptosis [86,87]. In an experiment by Draganov, it was found that the release of lactate dehydrogenase (LDH) and activated caspase-1 was significantly increased in breast cancer cells after IVM intervention [37]. In addition, characteristic pyroptosis phenomena such as cell swelling and rupturing were observed. The authors speculated that IVM may mediate the occurrence of pyroptosis via the P2 × 4/P2 × 7/NLRP3 pathway (Fig. 4), but there is no specific evidence to prove this speculation. Interestingly, in ischemia-reperfusion experiments, IVM aggravated renal ischemia via the P2 × 7/NLRP3 pathway and increased the release of proinflammatory cytokines in human proximal tubular cells [88]. Although there is currently little evidences showing that IVM induces pyroptosis, it is important to investigate the role of IVM in inducing pyroptosis in other cancers in future studies and realize that IVM may induce different types of programmed cell death in different types of cancer.

Fig. 4

Fig. 4

Mechanisms of IVM-induced P2 × 4/P2 × 7/NLRP3-mediated pyroptosis.

4. Anticancer effect of IVM through other pathways

4.1. Cancer stem cells

Cancer stem cells (CSCs) are a cell population similar to stem cells with characteristics of self-renewal and differentiation potential in tumor tissue [89,90]. Although CSCs are similar to stem cells in terms of function, because of the lack of a negative feedback regulation mechanism for stem cell self-renewal, their powerful proliferation and multidirectional differentiation abilities are unrestricted, which allows CSCs to maintain certain activities during chemotherapy and radiotherapy [[90][91][92]]. When the external environment is suitable, CSCs will rapidly proliferate to reactivate the formation and growth of tumors. Therefore, CSCs have been widely recognized as the main cause of recurrence after treatment [93,94]. Guadalupe evaluated the effect of IVM on CSCs in the breast cancer cell line MDA-MB-231 [95]. The experimental results showed that IVM would preferentially targeted and inhibited CSCs-rich cell populations compared with other cell populations in MDA-MB-231 cells. Moreover, the expression of the homeobox protein NANOG, octamer-binding protein 4 (OCT-4) and SRY-box 2 (SOX-2), which are closely related to the self-renewal and differentiation ability of stem cells in CSCs, were also significantly inhibited by IVM. This suggests that IVM may be used as a potential CSCs inhibitor for cancer therapy. Further studies showed that IVM could inhibit CSCs by regulating the PAK1-STAT3 axis [96].

4.2. Reversal of tumor multidrug resistance

MDR of tumor cells is the main cause of relapses and deaths after chemotherapy [97]. ATP binding transport family-mediated drug efflux and overexpression of P-glycoprotein (P-gp) are widely considered to be the main causes of tumor MDR [[98][99][100]]. Several studies have confirmed that IVM could reverse drug resistance by inhibiting P-gp and MDR-associated proteins [[101][102][103]]. In Didier’s experiments testing the effect of IVM on lymphocytic leukemia, IVM could be used as an inhibitor of P-gp to affect MDR [22]. In Jiang’s experiment, IVM reversed the drug resistance of the vincristine-resistant colorectal cancer cell line HCT-8, doxorubicin-resistant breast cancer cell line MCF-7 and the chronic myelogenous leukemia cell line K562 [104]. IVM inhibited the activation of EGFR and the downstream ERK/Akt/NF-kappa B signaling pathway to downregulate the expression of P-gp. Earlier, we mentioned the role of IVM in docetaxel-resistant prostate cancer [50] and gemcitabine-resistant cholangiocarcinoma [44]. These results indicated the significance of applying IVM for the treatment of chemotherapy patients with MDR.

4.3. Enhanced targeted therapy and combined treatment

Targeted treatment of key mutated genes in cancer, such as EGFR in lung cancer and HER2 in breast cancer, can achieve powerful clinical effects [105,106]. HSP27 is a molecular chaperone protein that is highly expressed in many cancers and associated with drug resistance and poor prognosis. It is considered as a new target for cancer therapy [107]. Recent studies have found that IVM could be used as an inhibitor of HSP27 phosphorylation to enhance the activity of anti-EGFR drugs in EGFR/HER2- driven tumors. An experiment found that IVM could significantly enhance the inhibitory effects of erlotinib and cetuximab on lung cancer and colorectal cancer [50]. Earlier, we mentioned that IVM combined with conventional chemotherapeutic drugs such as cisplatin [60], paclitaxel [59], daunorubicin and cytarabine [51], or with targeted drugs such as dasatinib [53] and dapafenib [73] shows great potential for cancer treatment. The combination of drugs can effectively increase efficacy, reduce toxicity or delay drug resistance. Therefore, combination therapy is the most common method of chemotherapy. IVM has a variety of different mechanisms of action in different cancers, and its potential for synergistic effects and enhanced efficacy in combination therapy was of particular interest to us. Not only does IVM not overlap with other therapies in term of its mechanism of action, but the fact that of IVM has multiple targets suggests that it is not easy to produce IVM resistance. Therefore, continued study and testing of safe and effective combination drug therapies is essential to maximize the anticancer effects of IVM.

5. Molecular targets and signaling pathways involved in the anticancer potential of IVM

As mentioned above, the anticancer mechanism of IVM involves a wide range of signaling pathways such as Wnt/β-catenin, Akt/mTOR, MAPK and other possible targets such as PAK1 and HSP27, as well as other mechanisms of action (Table 2 ). We found that IVM inhibits tumor cell development in a PAK1-dependent manner in most cancers. Consequently, we have concentrated on discussing the role of PAK1 kinase and cross-talk between various pathways and PAK1 to provide new perspectives on the mechanism of IVM function.

Table 2

Table 2

Summary of the anticancer mechanism of IVM

As a member of the PAK family of serine/threonine kinases, PAK1 has a multitude of biological functions such as regulating cell proliferation and apoptosis, cell movement, cytoskeletal dynamics and transformation [108]. Previous studies have indicated that PAK1 is located at the intersection of multiple signaling pathways related to tumorigenesis and is a key regulator of cancer signaling networks (Fig. 5). The excessive activation of PAK1 is involved in the formation, development, and invasion of various cancers [ 109,110]. Targeting PAK1 is a novel and promising method for cancer treatment, and the development of PAK1 inhibitors has attracted widespread attention [111]. IVM is a PAK1 inhibitor in a variety of tumors, and it has good safety compared to that of other PAK1 inhibitors such as IPA-3. In melanoma and nasopharyngeal carcinoma, IVM inhibited cell proliferation activity by inhibiting PAK1 to downregulate the expression of MEK 1/2 and ERK1/2 [69,73]. After IVM intervention in breast cancer, the expression of PAK1 was also significantly inhibited, and the use of siRNA to downregulate the expression of PAK1 in tumor cells significantly reduced the anticancer activity of IVM. Interestingly, IVM could inhibit the expression of PAK1 protein but did not affect the expression of PAK1 mRNA [32].The proteasome inhibitor MG132 reversed the suppressive effect of IVM, which indicated that IVM mainly degraded PAK1 via the proteasome ubiquitination pathway. We have already mentioned that IVM plays an anticancer role in various tumors by regulating pathways closely related to cancer development. PAK1 is at the junction of these pathways. Overall, we speculate that IVM can regulate the Akt/mTOR, MAPK and other pathways that are essential for tumor cell proliferation by inhibiting PAK1 expression, which plays an anticancer role in most cancers.

Fig. 5

Fig. 5

PAK1 cross regulates multiple signal pathways.

6. Summary and outlooks

Malignant tumors are one of the most serious diseases that threaten human health and social development today, and chemotherapy is one of the most important methods for the treatment of malignant tumors. In recent years, many new chemotherapeutic drugs have entered the clinic, but tumor cells are prone to drug resistance and obvious adverse reactions to these drugs. Therefore, the development of new drugs that can overcome resistance, improve anticancer activity, and reduce side effects is an urgent problem to be solved in chemotherapy. Drug repositioning is a shortcut to accelerate the development of anticancer drugs.

As mentioned above, the broad-spectrum antiparasitic drug IVM, which is widely used in the field of parasitic control, has many advantages that suggest that it is worth developing as a potential new anticancer drug. IVM selectively inhibits the proliferation of tumors at a dose that is not toxic to normal cells and can reverse the MDR of tumors. Importantly, IVM is an established drug used for the treatment of parasitic diseases such as river blindness and elephantiasis. It has been widely used in humans for many years, and its various pharmacological properties, including long- and short-term toxicological effects and drug metabolism characteristics are very clear. In healthy volunteers, the dose was increased to 2 mg/Kg, and no serious adverse reactions were found, while tests in animals such as mice, rats, and rabbits found that the median lethal dose (LD50) of IVM was 10-50 mg/Kg [112] In addition, IVM has also been proven to show good permeability in tumor tissues [50]. Unfortunately, there have been no reports of clinical trials of IVM as an anticancer drug. There are still some problems that need to be studied and resolved before IVM is used in the clinic.

(1) Although a large number of research results indicate that IVM affects multiple signaling pathways in tumor cells and inhibits proliferation, IVM may cause antitumor activity in tumor cells through specific targets. However, to date, no exact target for IVM action has been found. (2) IVM regulates the tumor microenvironment, inhibits the activity of tumor stem cells and reduces tumor angiogenesis and tumor metastasis. However, there is no systematic and clear conclusion regarding the related molecular mechanism. Therefore, in future research, it is necessary to continue to explore the specific mechanism of IVM involved in regulating the tumor microenvironment, angiogenesis and EMT. (3) It has become increasingly clear that IVM can induce a mixed cell death mode involving apoptosis, autophagy and pyroptosis depending on the cell conditions and cancer type. Identifying the predominant or most important contributor to cell death in each cancer type and environment will be crucial in determining the effectiveness of IVM-based treatments. (4) IVM can enhance the sensitivity of chemotherapeutic drugs and reduce the production of resistance. Therefore, IVM should be used in combination with other drugs to achieve the best effect, while the specific medication plan used to combine IVM with other drugs remains to be explored.

Most of the anticancer research performed on the avermectin family has been focused on avermectin and IVM until now. Avermectin family drugs such as selamectin [36,41,113], and doramectin [114] also have anticancer effects, as previously reported. With the development of derivatives of the avermectin family that are more efficient and less toxic, relevant research on the anticancer mechanism of the derivatives still has great value. Existing research is sufficient to demonstrate the great potential of IVM and its prospects as a novel promising anticancer drug after additional research. We believe that IVM can be further developed and introduced clinically as part of new cancer treatments in the near future.

Declaration of Competing Interest

The authors report no declarations of interest.

Acknowledgments

This work was supported by the Science Research Innovation Team Project of Anhui Colleges and Universities (2016-40), the Bengbu City Natural Science Foundation (2019-12), the Key Projects of Science Research of Bengbu Medical College (BYKY2019009ZD) and National University Students’ Innovation and Entrepreneurship Training Program (201910367001).

Article information

Pharmacol Res. 2021 Jan; 163: 105207. 

Published online 2020 Sep 21. doi: 10.1016/j.phrs.2020.105207

PMCID: PMC7505114

PMID: 32971268

Mingyang Tang,a,b,1 Xiaodong Hu,c,1 Yi Wang,a,d Xin Yao,a,d Wei Zhang,a,b Chenying Yu,a,b Fuying Cheng,a,b Jiangyan Li,a,d and  Qiang Fanga,d,e,*

aAnhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui Province 233030, China

bClinical Medical Department, Bengbu Medical College, Bengbu, Anhui Province 233030, China

cDepartment of Histology and Embryology, Bengbu Medical College, Bengbu, Anhui Province 233030, China

dDepartment of Microbiology and Parasitology, Bengbu Medical College, Bengbu, Anhui Province 233030, China

eSchool of Fundamental Sciences, Bengbu Medical College, Bengbu, Anhui Province 233030, China

Corresponding author at: Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui Province 233030, China.

1These authors contributed equally.

Received 2020 Jun 5; Revised 2020 Sep 11; Accepted 2020 Sep 11.

Copyright © 2020 Elsevier Ltd. All rights reserved.

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